GaOOH powders of submicron dimensions were synthesized through a simple, surfactant-free hydrothermal synthesis at pH values of 7 and 14. Sn and Cr at concentrations of 2 mol% and 1 mol%, respectively, were successfully incorporated into a GaOOH lattice at pH = 7. The synthesized powders were characterized through XRD, SEM, UV-Vis spectroscopy, XPS, and PL spectroscopy to untangle their structural, morphological, optical, elemental, and compositional- and defect-level analyses, respectively. All samples were individually tested for their in vitro anti-proliferation activities against three human cancer cell line profiles, namely, lung carcinoma (A549), colon adenocarcinoma (LoVo), and hepatocellular carcinoma (HuH-7). The samples showed obtrusive anti-proliferation activity against the three cancer line profiles. An apoptotic cell killing mechanism was found in the studied samples after a successful analysis of various staining assays and flowcytometric analyses in the A549 cancer cell profile. Cr loading at 1 mol% enhanced the cancer cell inhibition property of GaOOH against all cancer cells investigated. Also, the morphology and doping levels were observed to have a collective effect on the anti-proliferation activity of GaOOH with specificity in treating certain cancer cells.

在 pH 值为 7 和 14 时，通过简单的无表面活性剂水热合成法合成了亚微米尺寸的 GaOOH 粉末。浓度分别为 2 mol% 和 1 mol% 的 Sn 和 Cr 在 pH = 时成功地结合到 GaOOH 晶格中7. 通过 XRD、SEM、UV-Vis 光谱、XPS 和 PL 光谱对合成的粉末进行表征，以分别对它们的结构、形态、光学、元素以及成分和缺陷水平进行分析。所有样品都单独进行了体外测试针对三种人类癌细胞系谱的抗增殖活性，即肺癌 (A549)、结肠腺癌 (LoVo) 和肝细胞癌 (HuH-7)。样品对三种癌症谱系表现出明显的抗增殖活性。在成功分析 A549 癌细胞谱中的各种染色测定和流式细胞术分析后，在所研究的样品中发现了凋亡细胞杀伤机制。1 mol% 的 Cr 负载增强了 GaOOH 对所有研究的癌细胞的癌细胞抑制特性。此外，观察到形态和掺杂水平对 GaOOH 的抗增殖活性具有集体效应，并具有治疗某些癌细胞的特异性。