An electromagnetic energy source in the radio-frequency range delivers power to a stent circuit via resonant inductive coupling, allowing a thermally triggered release of gel via Joule heating. A gold-electroplated, medical-grade stainless steel stent, serving as the base of the prototype device, melts a coating made from an emulsion composed mainly of dodecanoic acid. These coated devices produce wirelessly controllable releases of a gel into thermally regulated, stirred water that is near body temperature. The gel is made from salt, water, and gelatine from porcine skin and used to simulate drug release in this study. Thus, this system serves as a proof of concept to show the viability of controlling local drug delivery using this prototype device. Dodecanoic acid, a fatty acid, has a phase transition from solid to liquid near 43\(^\circ\)C and has relatively good biocompatibility. The average melting temperature of two different emulsions was 40.8±0.7\(^\circ\)C, a suitable value for the targeted application. Demonstration of controllable releases used electromagnetic pulses of approximately 180 seconds in duration, illustrating reproducibility of a controllable release phase while remaining relatively inert in the absence of stimuli. Releases were observable through measuring the conductivity of the water, the water temperature, and the stent temperature. This electrothermally active stent device enables wirelessly controlled local delivery with controlled dosage and timing, a concept with a wide range of potential applications. Some relevant examples include inhibiting restenosis or cancer treatment via targeted chemotherapy.

射频范围内的电磁能源通过谐振电感耦合向支架电路供电，允许通过焦耳加热热触发凝胶释放。一个镀金的医疗级不锈钢支架，作为原型设备的基础，熔化由主要由十二烷酸组成的乳液制成的涂层。这些带涂层的设备可以无线控制将凝胶释放到接近体温的温度调节、搅拌的水中。该凝胶由盐、水和猪皮中的明胶制成，用于模拟本研究中的药物释放。因此，该系统用作概念证明，以展示使用该原型设备控制局部药物输送的可行性。十二烷酸是一种脂肪酸，在 43 ℃附近具有从固体到液体的相变\(^\circ\) C，具有较好的生物相容性。两种不同乳液的平均熔融温度为 40.8±0.7 \(^\circ\)C，适合目标应用的值。可控释放的演示使用持续时间约为 180 秒的电磁脉冲，说明可控释放阶段的可重复性，同时在没有刺激的情况下保持相对惰性。通过测量水的电导率、水温和支架温度可以观察到释放。这种电热活性支架装置能够以受控的剂量和时间进行无线控制的局部递送，这一概念具有广泛的潜在应用。一些相关的例子包括通过靶向化疗抑制再狭窄或癌症治疗。