Construction of a microRNA–mRNA Regulatory Network in De Novo Cytogenetically Normal Acute Myeloid Leukemia Patients,Genetic Testing and Molecular Biomarkers

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Construction of a microRNA–mRNA Regulatory Network in De Novo Cytogenetically Normal Acute Myeloid Leukemia Patients
Genetic Testing and Molecular Biomarkers ( IF 1.1 ) Pub Date : 2021-03-17 , DOI: 10.1089/gtmb.2020.0182
Ezalia Esa ₁ , Ariwibawa Kasmani Hashim ₂ , Elsa Haniffah Mejia Mohamed ₂ , Zubaidah Zakaria ₂ , Alifah Nadia Abu Hassan ₁ , Yuslina Mat Yusoff ₁ , Nor Rizan Kamaluddin ₁ , Ahmad Zuhairi Abdul Rahman ₁ , Kian-Meng Chang ₃ , Rashidah Mohamed ₃ , Indhira Subbiah ₄ , Ehram Jamian ₄ , Caroline Siew-Ling Ho ₄ , Soo-Min Lim ₄ , Peng-Choon Lau ₅ , Yuh-Fen Pung ₆ , Shamsul Mohd Zain ₂

Affiliation

Background: The association between dysregulated microRNAs (miRNAs) and acute myeloid leukemia (AML) is well known. However, our understanding of the regulatory role of miRNAs in the cytogenetically normal AML (CN-AML) subtype pathway is still poor. The current study integrated miRNA and mRNA profiles to explore novel miRNA–mRNA interactions that affect the regulatory patterns of de novo CN-AML.

中文翻译：

新生细胞遗传学正常急性髓系白血病患者microRNA-mRNA调控网络的构建

背景：微RNA（miRNA）失调与急性髓系白血病（AML）之间的关联是众所周知的。然而，我们对 miRNA 在细胞遗传学正常的 AML (CN-AML) 亚型途径中的调节作用的理解仍然很差。目前的研究整合了 miRNA 和 mRNA 谱，以探索影响de novo CN-AML调控模式的新型 miRNA-mRNA 相互作用。

更新日期：2021-03-19

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