Dementia with Lewy bodies (DLB) and Parkinson's disease‐dementia (PDD) are two major neurocognitive disorders in the spectrum of Lewy body dementia (LBD) that overlap in many clinical and neuropathological features, although they show minimal differences [1]. Their morphology is characterized by a variable combination of Lewy body disease (LBD) and Alzheimer disease (AD)‐related pathologies, the latter usually being more severe in DLB [2,3]. Cerebral amyloid angiopathy (CAA) is very common in AD with a prevalence up to 97% [4]. Recently, Hansen et al [5], comparing 52 autopsy cases of PDD and 16 DLB cases, showed that CAA was more common and more severe in DLB than in PDD (p=0.003 and 0.009, respectively), with significantly higher CAA scores in the occipital and parietal lobes.

中文翻译：

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路易体痴呆与帕金森病痴呆的形态学差异

路易体痴呆 (DLB) 和帕金森病痴呆 (PDD) 是路易体痴呆 (LBD) 谱系中的两种主要神经认知障碍，尽管它们的差异很小，但它们在许多临床和神经病理学特征上重叠 [1]。它们的形态特征是路易体病 (LBD) 和阿尔茨海默病 (AD) 相关病理的可变组合，后者通常在 DLB 中更严重 [2,3]。脑淀粉样血管病 (CAA) 在 AD 中非常常见，患病率高达 97% [4]。最近，Hansen 等人 [5] 比较了 52 例 PDD 和 16 例 DLB 的尸检，发现 CAA 在 DLB 中比在 PDD 中更常见和更严重（分别为 p=0.003 和 0.009），在枕叶和顶叶。