The isoxazolines are a novel class of ectoparasiticides with potent inhibitory activity on glutamate- and gamma-aminobutyric acid-gated chloride channel located in nervous system of invertebrates. In recent years, studies have been performed to evaluate the efficacy and safety of isoxazolines against various types of ectoparasites, including fleas, ticks, and mites. As more single and combined isoxazoline products have been approved by the United States Food and Drug Administration and European Medicines Agency, a more comprehensive understanding of isoxazolines becomes essential for veterinary clinical practitioners. This article provides a complete review of isoxazolines with respect to pharmacodynamics, pharmacokinetics, ectoparasiticidal efficacy, and safety, which will provide veterinarians information to allow them to make the best choice of ectoparasiticide for their clients’ specific needs.

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兽药中使用的异恶唑啉外寄生虫剂的最新综述

异恶唑啉是一类新型的外寄生虫药，对位于无脊椎动物神经系统的谷氨酸和γ-氨基丁酸门控氯离子通道具有强效抑制活性。近年来，已经进行了研究以评估异恶唑啉对各种类型的体外寄生虫（包括跳蚤、蜱虫和螨虫）的疗效和安全性。随着越来越多的单一和组合异恶唑啉产品获得美国食品药品监督管理局和欧洲药品管理局的批准，对异恶唑啉更全面的了解对于兽医临床从业者来说变得至关重要。本文对异恶唑啉的药效学、药代动力学、杀外寄生虫功效和安全性进行了完整的综述，