Isfahan as an important industrial city has faced with air pollution recently. Thus, we assessed the spatial and temporal trends of ambient PM_2.5, CO, SO₂, and O₃ and for estimating their health effect on Isfahan citizens between March 2018 and March 2019 through the AirQ+ software. Our results showed that citizens of Isfahan in almost 240, 167, and 134 of the days in the year has exposure to PM_2.5, SO₂, and O₃ higher than the WHO daily guideline, respectively. Daily variations of PM_2.5, CO, and SO₂ concentration showed the increasing trend of pollutants in the morning to evening. The maximum concentrations of O₃ were observed in the noonday. Also, the concentrations of these pollutants on Friday due to the holiday effect were higher than the weekdays. Except for O₃, the PM_2.5, CO, and SO₂ concentrations in the cold months and cold seasons was higher compared with the hot months and hot seasons. The total number of deaths because of lung cancer, natural mortality, ischemic heart disease, chronic obstructive pulmonary disease,, stroke associated with ambient PM_2.5 with the attributable proportion (AP) 11.43%, 11.63%, 15.96%, 15.15%, and 13.1% (95% CI) were 683, 19, 2, 202, and 55 cases, respectively. Therefore, the present study provides additional data for the provincial managers and politicians useful in planning proper strategies of air pollution control to decrease exposure and attributable mortalities.

伊斯法罕作为重要的工业城市，近期面临空气污染问题。因此，我们通过 AirQ+ 软件评估了环境 PM _2.5、CO、SO ₂和 O ₃的空间和时间趋势，并估计它们在 2018 年 3 月至 2019 年 3 月期间对伊斯法罕公民的健康影响。我们的研究结果表明，伊斯法罕市民在一年中有近 240 天、167 天和 134 天的 PM _2.5、SO ₂和 O ₃暴露量分别高于世卫组织每日指南。PM _2.5、CO 和SO ₂浓度的日变化显示污染物从早到晚呈上升趋势。_{O 3}的最大浓度中午观察到。此外，由于假期影响，周五这些污染物的浓度高于平日。除O ₃外，冷月和冷季PM _2.5、CO 和SO ₂浓度均高于热月和热季。因肺癌、自然死亡率、缺血性心脏病、慢性阻塞性肺病、与环境 PM _{2.5相关的中风而导致的死亡总数}归因比例（AP）11.43%、11.63%、15.96%、15.15%和13.1%（95% CI）分别为683、19、2、202和55例。因此，本研究为省级管理者和政治家提供了额外的数据，有助于规划适当的空气污染控制策略，以减少暴露和可归因的死亡率。