Clozapine is under-used in the UK, and Casetta et al's recent paper in the BJPsych adds to a growing number of small studies that support the use of intramuscular clozapine to initiate and maintain treatment with oral clozapine. However, intramuscular clozapine remains unlicensed and, because of the risks associated with its administration, it should be used only cautiously before it can be adopted more widely into mainstream clinical practice.

中文翻译：

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肌注氯氮平是否应纳入主流临床实践？

氯氮平在英国使用不足，Casetta 等人最近在BJPsych上发表的论文增加了越来越多的小型研究，这些研究支持使用肌肉注射氯氮平来启动和维持口服氯氮平治疗。然而，肌肉注射氯氮平仍然未经许可，并且由于其给药存在风险，在其被更广泛地应用于主流临床实践之前，应谨慎使用。