Purpose

The present work aims to prepare a controlled release matrix, using biodegradable materials containing different active ingredients (AI) in order to deliver only the necessary dose for a specific time and a well-defined target.

Methods

The matrix is a manual sheet, composed of lignocellulosic fibers. The membrane, which regulates the release, is obtained by immersing the sheet in an emulsion of polyvinyl acetate. Different thicknesses were deposited by varying the concentration of the emulsion. Five AIs, which differ in volume and solubility, were used as probes: salicylic acid (SA), acetylsalicylic acid (ASA), metoclopramide (MCP), ketoprofen (KP), and thiocolchicoside (TCC).

Results

Kinetic studies have shown that the release of these substances is strongly related to the pH, the solubility of the AI, the thickness, and the permeability of the polymer membrane. The kinetics of release of AI are zero order in an acidic medium and complex in a basic medium. The images taken by scanning electron microscopy (SEM) show the variation in thickness with the number of layers of emulsion deposited.

Conclusions

Our system, paper coated with a polyvinyl-acetate (PVAc) emulsion film without a coalescing agent has proven to be a promising matrix for achieving the controlled release of different IAs. It suffices only to adjust the thickness of the membrane. The process is simple and easy compared with other recently developed extended release matrices.

中文翻译：

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聚醋酸乙烯酯涂层的手抄纸作为药物释放系统

目的

本工作旨在使用含有不同活性成分（AI）的可生物降解材料制备控释基质，以便在特定时间内仅提供必要的剂量和明确的目标。

方法

基质是由木质纤维素纤维组成的手工纸。通过将片浸入聚乙酸乙烯酯的乳液中来获得调节释放的膜。通过改变乳液的浓度来沉积不同的厚度。体积和溶解度不同的五个AI被用作探针：水杨酸（SA），乙酰水杨酸（ASA），甲氧氯普胺（MCP），酮洛芬（KP）和硫代秋水仙苷（TCC）。

结果

动力学研究表明，这些物质的释放与pH值，AI的溶解度，厚度和聚合物膜的渗透性密切相关。AI的释放动力学在酸性介质中为零级，而在碱性介质中为复合物。扫描电子显微镜（SEM）拍摄的图像显示了厚度随乳剂沉积层数的变化。

结论

我们的系统，涂有不含聚结剂的聚乙酸乙烯酯（PVAc）乳胶膜的纸，已被证明是实现不同IA受控释放的有前途的基质。仅调整膜的厚度就足够了。与其他最近开发的扩展发行版矩阵相比，该过程既简单又容易。