The emergence of a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has become a significant health concern worldwide. Undoubtedly, a better understanding of the innate and adaptive immune responses against SARS-CoV-2 and its relationship with the coronavirus disease 2019 (COVID-19) pathogenesis will be the sole basis for developing and applying therapeutics. This review will summarize the published results that relate to innate immune responses against infections with human coronaviruses including SARS-CoV-1 and SARS-CoV-2 in both humans and animal models. The topics encompass the innate immune sensing of the virus to the dysregulation of various innate immune cells during infection and disease progression.

中文翻译：

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了解宿主对SARS-CoV-2感染和COVID-19发病机制的先天免疫反应。

新的严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）大流行的出现已成为全球关注的重大健康问题。毫无疑问，对SARS-CoV-2的先天性和适应性免疫反应及其与2019年冠状病毒病（COVID-19）发病机理的关系的更好理解将是开发和应用治疗剂的唯一基础。这篇综述将总结有关在人类和动物模型中针对人类冠状病毒（包括SARS-CoV-1和SARS-CoV-2）感染的先天免疫应答的已发表结果。主题包括病毒在感染和疾病进展过程中对各种先天免疫细胞失调的先天免疫感应。