The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 has severely impacted global health and economy. There is currently no effective approved treatment for COVID-19; although vaccines have been granted emergency use authorization in several countries, they are currently only administered to high-risk individuals, thereby leaving a gap in virus control measures. The scientific and clinical communities and drug manufacturers have collaborated to speed up the discovery of potential therapies for COVID-19 by taking advantage of currently approved drugs as well as investigatory agents in clinical trials. In this review, we stratified some of these candidates based on their potential targets in the progression of COVID-19 and discuss some of the results of ongoing clinical evaluations.

中文翻译：

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COVID-19 抗病毒药物和治疗候选药物：当前状态。


由严重急性呼吸系统综合症冠状病毒 2 引起的 2019 年冠状病毒病（COVID-19）大流行严重影响了全球健康和经济。目前尚无有效的经批准治疗 COVID-19 的方法；尽管疫苗已在多个国家获得紧急使用授权，但目前仅对高危人群进行接种，从而在病毒控制措施方面留下了空白。科学界和临床界以及药品制造商合作，利用目前已批准的药物以及临床试验中的研究药物，加快发现 COVID-19 的潜在疗法。在这篇综述中，我们根据其中一些候选药物在 COVID-19 进展中的潜在目标对它们进行了分层，并讨论了正在进行的临床评估的一些结果。