2, 3-Dihydroquinazolinones are of popular compounds with the diversification of biological and pharmacological activities. Among many discovered methods, there are efficient and convenient methods used for the synthesis of 2, 3-dihydroquinazoline-4 (1H)-one and some new bis 2, 3- dihydroquinazoline-4 (1H)-one derivatives which are reported in this study. The mentioned methods include the two-component condensation of one molecule of anthranilamide and one molecule of pyrazole carbaldehyde using montmorillonite-K10 as a catalyst for the preparation of 2, 3 dihydroquinazoline- 4 (1H)-ones. Also, one-pot pseudo-five-component reaction (5MCRs) of two molecules of isatoic anhydride, two molecules of pyrazole carbaldehydes and one molecule of ethan-1, 2-diamine in the presence of the r catalyst (montmorillonite-K10) for the synthesis of bis 2, 3-dihydroquinazoline-4 (1H)-ones. Despite the short times of reactions, high yields of products were obtained, which were validated using FT-IR, ¹HNMR, ¹³CNMR, and elemental analysis. Moreover, the compounds were screened for their antimicrobial activities against two-gram-positive bacterial strains: Staphylococcus aureus and Micrococcus Luteus; and against two-gram-negative bacterial strains, as well: Escherichia coli and Pseudomonas aeruginosa, which all were utilized for antibacterial investigations. The results showed moderate or significant antibacterial activities.

2，3-二氢喹唑啉酮是流行的化合物，具有多种生物和药理活性。在许多发现的方法中，有高效而便捷的方法可用于合成2，3-二氢喹唑啉-4（1H）-one和一些新的bis 2，3-二氢喹唑啉-4（1H）-one衍生物。学习。所提及的方法包括使用蒙脱石-K10作为催化剂制备2，3二氢喹唑啉-4（1H）-一的一分子蒽酰胺和一分子吡唑甲醛的两组分缩合。同样，在存在r催化剂（蒙脱土-K10）的情况下，两分子等位酸酐，两分子吡唑甲醛和一分子ethan-1、2-二胺的一锅法假五组分反应（5MCR）用于二之二的合成 3-二氢喹唑啉-4（1H）-ones。尽管反应时间短，但仍获得了高收率的产品，这已通过FT-IR进行了验证，¹ HNMR，¹³ CNMR和元素分析。此外，筛选了化合物对两克阳性细菌菌株：金黄色葡萄球菌和黄球微球菌的抗微生物活性。以及针对两克阴性细菌菌株：大肠杆菌和铜绿假单胞菌（Pseudomonas aeruginosa），它们均用于抗菌研究。结果显示中等或显着的抗菌活性。