Steric and electronic effects on the 1H hyperpolarisation of substituted pyridazines by signal amplification by reversible exchange,Magnetic Resonance in Chemistry

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Steric and electronic effects on the 1H hyperpolarisation of substituted pyridazines by signal amplification by reversible exchange
Magnetic Resonance in Chemistry ( IF 1.9 ) Pub Date : 2021-03-17 , DOI: 10.1002/mrc.5152
Peter J Rayner ₁ , Michael J Burns ₁ , Elizabeth J Fear ₁ , Simon B Duckett ₁

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Utility of the pyridazine motif is growing in popularity as pharmaceutical and agrochemical agents. The detection and structural characterisation of such materials is therefore imperative for the successful development of new products. Signal amplification by reversible exchange (SABRE) offers a route to dramatically improve the sensitivity of magnetic resonance methods, and we apply it here to the rapid and cost-effective hyperpolarisation of substituted pyridazines. The 33 substrates investigated cover a range of steric and electronic properties and their capacity to perform highly effective SABRE is assessed. We find the method to be tolerant to a broad range of electron donating and withdrawing groups; however, good sensitivity is evident when steric bulk is added to the 3- and 6-positions of the pyridazine ring. We optimise the method by reference to a disubstituted ester that yields signal gains of >9000-fold at 9.4 T (>28% spin polarisation).

中文翻译：

通过可逆交换信号放大对取代哒嗪 1H 超极化的空间和电子效应

哒嗪基序作为药物和农用化学品的用途越来越受欢迎。因此，此类材料的检测和结构表征对于新产品的成功开发至关重要。可逆交换信号放大（SABRE）提供了一种显着提高磁共振方法灵敏度的途径，我们将其应用于取代哒嗪的快速且经济有效的超极化。研究的 33 种基材涵盖了一系列空间和电子特性，并评估了它们执行高效 SABRE 的能力。我们发现该方法能够耐受广泛的给电子基团和吸电子基团；然而，当空间体积添加到哒嗪环的 3 位和 6 位时，明显具有良好的灵敏度。我们通过参考二取代酯来优化该方法，该二取代酯在 9.4 T 下产生 > 9000 倍的信号增益（> 28% 自旋极化）。

更新日期：2021-03-17

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