Background: Menopause and estrogen deprivation cause a rise in the number of urogenital tract complaints. Objective: This study was conducted to assess the effectiveness of ginseng on genitourinary syndrome. Methods: This randomized trial was conducted on 60 postmenopausal women with genitourinary syndrome. The participants were randomly allocated to ginseng and placebo groups twice daily for 4 weeks. Vaginal maturation index and vaginal pH were evaluated before and 4 weeks after intervention as the primary outcomes. Also, the atrophic vaginitis and incontinence questionnaires were completed before and after intervention as the secondary outcomes. The safety of intervention was assessed by the side effects checklist. Results: No significant differences were observed between the 2 groups in objective symptoms after the intervention, but the difference was statistically significant (p #x3c; 0.001) in terms of subjective symptoms of atrophic vaginitis. One case of insomnia and palpitation and 2 cases of hot flashes were reported in the intervention group, and 1 case of gastric discomfort and change in urine appearance was reported in the placebo group. Conclusion: Ginseng only improved the patient-assessed symptoms and had no significant effect on the clinician-assessed outcomes. Further studies are required to determine the precise pharmacological mechanisms of ginseng on genitourinary syndrome.
Complement Med Res

中文翻译：

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人参对绝经后妇女泌尿生殖系统综合征的影响：一项随机、双盲、安慰剂对照的临床试验

背景：更年期和雌激素缺乏导致泌尿生殖道不适的数量增加。目的：本研究旨在评估人参对泌尿生殖系统综合征的疗效。方法：这项随机试验对 60 名患有泌尿生殖系统综合症的绝经后妇女进行。参与者被随机分配到人参组和安慰剂组，每天两次，持续 4 周。在干预前和干预后 4 周评估阴道成熟指数和阴道 pH 值作为主要结果。此外，在干预前后完成萎缩性阴道炎和失禁问卷作为次要结果。通过副作用检查表评估干预的安全性。结果：干预后两组客观症状差异无统计学意义，但萎缩性阴道炎主观症状差异有统计学意义（p #x3c；0.001）。干预组出现失眠心悸1例，潮热2例，安慰剂组出现胃部不适和尿样改变1例。结论：人参仅改善了患者评估的症状，对临床医生评估的结果没有显着影响。需要进一步的研究来确定人参对泌尿生殖系统综合征的确切药理机制。
补充医学资源