The aim of this review is to discuss recent evidence on cannabis and driving ability, In particular, the review examines experimental research on the acute effects of tetrahydrocannabinol (THC) on driving-related neurobehavioral skills and driving performance based on simulator and road course studies. The evidence indicates that certain driving abilities are significantly, albeit modestly, impaired in individuals experiencing the acute effects of THC. Treatment effects are moderated by dose, delivery method, recency of use, and tolerance development, with inconclusive evidence concerning the moderating influence of cannabidiol (CBD). Emerging research priorities include linking neurobehavioral deficits to specific decrements in driving performance, estimating the real-world implications of experimentally derive impairment effects, understanding how tolerance differentially affects driving impairment in different subgroups, and developing more evidence on CBD’s potential role in mitigating THC-induced impairment.

本综述的目的是讨论有关大麻和驾驶能力的最新证据，特别是，该综述基于模拟器和道路课程研究，审查了四氢大麻酚 (THC) 对驾驶相关神经行为技能和驾驶表现的急性影响的实验研究。有证据表明，在经历 THC 急性影响的个体中，某些驾驶能力会受到严重（尽管适度）的损害。治疗效果受到剂量、给药方法、使用新近度和耐受性发展的调节，关于大麻二酚 (CBD) 的调节作用尚无确凿证据。新兴的研究重点包括将神经行为缺陷与驾驶表现的具体下降联系起来，估计实验得出的损伤效应对现实世界的影响，了解耐受性如何对不同亚组的驾驶损伤产生不同的影响，以及开发更多关于 CBD 在减轻 THC 引起的驾驶损伤方面的潜在作用的证据损害。