Poststroke depression (PSD) is the most frequent complication after stroke. Statin is a widely used prophylactic for stroke. However, some researchers reported that poststroke statin may lead to a depressive change in stroke patients. We aimed to study the effect of different statin medication timing especially prestroke timing on PSD to adopt appropriate intervention around stroke. Patients with first-ever ischemic stroke were consecutively observed from January 2012 to June 2017. They were grouped by different initiation time of statin treatment. The follow-up endpoints were set to: (1) diagnosis of PSD within 1-year and (2) censor data. Cox regression model adjusted for confounding factors was performed. A total of 1571 patients were included in the analyses, among which 210 (13.4%) were comorbided with PSD, and the median time of the course was 30 (14-98) days. The patients who received both pre- and poststroke statin treatment had 1.99 times (P = 0.037) the hazard faced by patients who did not receive that medication. In contrast, sole statin pretreatment may have the tendency to reduce the risk of PSD. Our findings provide the primary results for the prestroke statin medication. The initiation timing of continuous regular statin treatment ahead of ischemic stroke could have a correlation with a higher risk of PSD.

中文翻译：

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他汀类药物对首次缺血性卒中患者抑郁症的反常作用：卒中前可能产生抗抑郁药样作用，卒中后连续用药则相反。

卒中后抑郁（PSD）是卒中后最常见的并发症。他汀类药物是一种广泛使用的中风预防剂。然而，一些研究人员报告说，中风后他汀类药物可能会导致中风患者出现抑郁的变化。我们的目的是研究不同他汀类药物用药时间特别是卒中前时间对 PSD 的影响，以便在卒中周围采取适当的干预措施。2012 年 1 月至 2017 年 6 月连续观察首次缺血性脑卒中患者，按不同的他汀类药物治疗起始时间分组。随访终点设置为：(1) 1 年内诊断 PSD 和 (2) 审查数据。进行了针对混杂因素调整的 Cox 回归模型。共有 1571 名患者被纳入分析，其中 210 名（13.4%）合并有 PSD，课程的中位时间为 30 (14-98) 天。接受卒中前和卒中后他汀类药物治疗的患者的风险是未接受该药物的患者的 1.99 倍 (P = 0.037)。相比之下，单独的他汀类药物预处理可能有降低 PSD 风险的趋势。我们的研究结果提供了卒中前他汀类药物治疗的主要结果。缺血性卒中前连续常规他汀类药物治疗的起始时间可能与较高的 PSD 风险相关。我们的研究结果提供了卒中前他汀类药物治疗的主要结果。缺血性卒中前连续常规他汀类药物治疗的起始时间可能与较高的 PSD 风险相关。我们的研究结果提供了卒中前他汀类药物治疗的主要结果。缺血性卒中前连续常规他汀类药物治疗的起始时间可能与较高的 PSD 风险相关。