Abstract

Due to the high adaptability of Helicobacter pylori and the low targeting specificity of the drugs normally used in pharmacological therapy, the strains are becoming increasingly resistant to these drugs, making it difficult to eradicate the infection. Thus, the search for new therapeutic approaches has been considered urgent. The incorporation of drugs in advanced drug delivery systems, such as nano and microparticles, would allow the improvement of the retention time in the stomach and the prolongation of drug release rates at the target site. Because of this, the present review article aims to highlight the use of micro and nanoparticles as important technological tools for the treatment of H. pylori infections, focussing on the main nanotechnological systems, including nanostructured lipid carriers, liposomes, nanoemulsion, metallic nanoparticles, and polymeric nanoparticles, as well as microtechnological systems such as gastroretentive dosage forms, among them mucoadhesive, magnetic and floating systems were highlighted.

摘要

由于幽门螺杆菌适应性强，药物治疗中常用药物的靶向特异性低，菌株对这些药物的耐药性越来越强，难以根除感染。因此，迫切需要寻找新的治疗方法。在先进的药物递送系统中加入药物，例如纳米和微粒，将允许改善在胃中的保留时间和延长靶位的药物释放速率。因此，本综述文章旨在强调使用微米和纳米粒子作为治疗幽门螺杆菌的重要技术工具。 感染方面，重点介绍了主要的纳米技术系统，包括纳米结构脂质载体、脂质体、纳米乳剂、金属纳米颗粒和聚合物纳米颗粒，以及胃滞留剂型等微技术系统，其中重点介绍了粘膜粘附系统、磁性系统和漂浮系统。