Aluminium (Al) water pollution is an increasing environmental problem. Accordingly, this study aimed to find out more about its toxic effects on aquatic organisms. Adult zebrafish were exposed to 11 mg/L of Al and the behavioural responses and its correlation with brain oxidative stress, antioxidant-defences, changes in metabolism and neurotransmission were assessed at 10, 15 and 20 days of exposure. The behavioural and locomotory responses, suggest an increase in the anxiety state, especially observed in animals exposed to Al for 15 days. The reactive oxygen species increased in a time-dependent trend, while the oxidative damage varied over exposure time. The activity of antioxidant enzymes, as superoxide dismutase, glutathione peroxidase and glutathione S-transferases, and the metallothioneins levels increased after short-term exposures and tended to decrease or stabilize at longer times. The results contribute to understand the toxic mechanisms activated by Al highlighting correlations like behavioural disorders and oxidative state.

铝 (Al) 水污染是一个日益严重的环境问题。因此，本研究旨在更多地了解其对水生生物的毒性作用。成年斑马鱼暴露于 11 毫克/升的铝，在暴露 10、15 和 20 天时评估行为反应及其与脑氧化应激、抗氧化防御、代谢和神经传递的变化的相关性。行为和运动反应表明焦虑状态增加，尤其是在暴露于铝 15 天的动物中观察到。活性氧以时间依赖的趋势增加，而氧化损伤随暴露时间而变化。抗氧化酶的活性，如超氧化物歧化酶、谷胱甘肽过氧化物酶和谷胱甘肽 S-转移酶，金属硫蛋白水平在短期暴露后增加，并在较长时间内趋于降低或稳定。结果有助于理解由 Al 激活的毒性机制，突出了行为障碍和氧化状态等相关性。