In order to enhance the antibacterial activity and reduce the toxicity of Zn2+, novel complexes of Zn(II) were synthesized. A water-soluble zinc-glucose-citrate complex (ZnGC) with antibacterial activity was synthesized at pH 6.5. The structure, morphology, characterization, acute toxicity, antibacterial and antioxidant activities, and in situ intestinal absorption were investigated. The results showed that zinc ion was linked with citrate by coordinate bond while the glucose was linked with it through intermolecular hydrogen bonding. The higher the molecular weight of sugar is, the more favorable it is to inhibit the formation of zinc citrate precipitation. Compared with ZnCl2, ZnGC complex presented better antibacterial activity against Staphylococcus aureus (S. aureus, Gram-positive) and Escherichia coli (E. coli, Gram-negative). The results of acute toxicity showed no obvious toxicity in this test and in situ intestinal absorption study, suggesting that ZnGC complex could be used as a potential zinc supplement for zinc deficiency.

中文翻译：

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具有抗菌和抗氧化活性的新型锌配合物

为了增强抗菌活性并降低Zn2 +的毒性，合成了新型的Zn（II）配合物。在pH 6.5下合成了具有抗菌活性的水溶性锌-葡萄糖-柠檬酸锌复合物（ZnGC）。研究了其结构，形态，特征，急性毒性，抗菌和抗氧化活性以及原位肠道吸收。结果表明，锌离子通过配位键与柠檬酸根键合，而葡萄糖通过分子间氢键与柠檬酸根键合。糖的分子量越高，抑制柠檬酸锌沉淀的形成越有利。与ZnCl2相比，ZnGC复合物对金黄色葡萄球菌（金黄色葡萄球菌，革兰氏阳性）和大肠杆菌（大肠杆菌，革兰氏阴性）表现出更好的抗菌活性。