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A Review of Research Progress on Agathis dammara and its Application Prospects for Cardiovascular Diseases and Fatty Liver Disease
Mini-Reviews in Medicinal Chemistry ( IF 3.3 ) Pub Date : 2021-03-31 , DOI: 10.2174/1389557520666201117110834
Anyi Wang 1 , Shanshan Yue 1 , Ankang Peng 1 , Rong Qi 1
Affiliation  

Cardiovascular diseases and fatty liver disease have become the leading causes of death in modern society. However, the currently existing drugs do not solve all issues related to these diseases; thus, it is expected that more potential drugs for clinical use will be developed. Undeniably, natural products have attracted increasing attention. It is of great significance to identify effective active monomer components for drug discovery and disease prevention. As a pure natural product, Agathis dammara (AD) has antioxidant, hypolipidemic, hypoglycemic, antitumor, and anti-inflammatory activities. However, at present, there are few reports regarding the effects of AD on chronic inflammatory cardiovascular diseases, such as aneurysm, atherosclerosis, myocardial ischemia-reperfusion injury, and cardiac hypertrophy and liver diseases such as fatty liver disease. AD and products derived from it have a very broad application prospect for cardiovascular diseases and fatty liver disease.



中文翻译:

ga螺的研究进展及其在心血管疾病和脂肪肝疾病中的应用前景

心血管疾病和脂肪肝疾病已成为现代社会死亡的主要原因。但是,目前存在的药物并不能解决与这些疾病有关的所有问题。因此,预计将开发出更多的临床潜在药物。不可否认,天然产品已引起越来越多的关注。鉴定有效的活性单体成分对于药物发现和疾病预防具有重要意义。作为纯天然产品,Agathis dammara(AD)具有抗氧化剂,降血脂,降血糖,抗肿瘤和抗炎活性。但是,目前,关于AD对慢性炎症性心血管疾病(如动脉瘤,动脉粥样硬化,心肌缺血-再灌注损伤,以及心脏肥大和肝脏疾病,例如脂肪肝。AD及其衍生产品在心血管疾病和脂肪肝疾病中具有非常广阔的应用前景。

更新日期:2021-03-16
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