Issues caused by maxillofacial tumours involve not only dealing with tumours but also repairing jaw bone defects. In traditional tumour therapy, the systemic toxicity of chemotherapeutic drugs, invasive surgical resection, intractable tumour recurrence, and metastasis are major threats to the patients’ lives in the clinic. Fortunately, biomaterial-based intervention can improve the efficiency of tumour treatment and decrease the possibility of recurrence and metastasis, suggesting new promising antitumour therapies. In addition, maxillofacial bone tissue defects caused by tumours and their treatment can negatively affect the physiological and psychological health of patients, and investment in treatment can result in a multitude of burdens to society. Biomaterials are promising options because they have good biocompatibility and bioactive properties for stimulation of bone regeneration. More interestingly, an integrated material regimen that combines tumour therapy with bone repair is a promising treatment option. Herein, we summarized traditional and biomaterial-mediated maxillofacial tumour treatments and analysed biomaterials for bone defect repair. Furthermore, we proposed a promising and superior design of dual-functional biomaterials for simultaneous tumour therapy and bone regeneration to provide a new strategy for managing maxillofacial tumours and improve the quality of life of patients in the future.

颌面部肿瘤带来的问题不仅涉及肿瘤的治疗，还涉及颌骨缺损的修复。在传统的肿瘤治疗中，化疗药物的全身毒性、侵入性手术切除、顽固性肿瘤复发和转移是临床上对患者生命的主要威胁。幸运的是，基于生物材料的干预可以提高肿瘤治疗的效率，降低复发和转移的可能性，为新的抗肿瘤治疗提供了希望。此外，肿瘤引起的颌面部骨组织缺损及其治疗会对患者的生理和心理健康产生负面影响，治疗投入会给社会带来诸多负担。生物材料是有前途的选择，因为它们具有良好的生物相容性和刺激骨再生的生物活性特性。更有趣的是，将肿瘤治疗与骨修复相结合的综合材料方案是一种很有前途的治疗选择。在此，我们总结了传统的和生物材料介导的颌面部肿瘤治疗方法，并分析了用于骨缺损修复的生物材料。此外，我们提出了一种用于同时进行肿瘤治疗和骨再生的双功能生物材料的有前途且优越的设计，为未来管理颌面部肿瘤和改善患者生活质量提供了新的策略。我们总结了传统的和生物材料介导的颌面部肿瘤治疗方法，并分析了用于骨缺损修复的生物材料。此外，我们提出了一种用于同时进行肿瘤治疗和骨再生的双功能生物材料的有前途且优越的设计，为未来管理颌面部肿瘤和改善患者生活质量提供了新的策略。我们总结了传统的和生物材料介导的颌面部肿瘤治疗方法，并分析了用于骨缺损修复的生物材料。此外，我们提出了一种用于同时进行肿瘤治疗和骨再生的双功能生物材料的有前途且优越的设计，为未来管理颌面部肿瘤和改善患者生活质量提供了新的策略。