Endometrial endometrioid carcinoma (EEC) represents approximately 75-80% of endometrial carcinoma cases. Three hundred thirty-six patients with EEC followed-up in the authors' institutions between and 2010-2018 were included in our study. Two hundred seventy-two low- and intermediate- EEC patients were identified using the European Society for Medical Oncology criteria and confirmed by histopathological examination. Recurrence was reported in 17 of these patients. The study group consisted of patients with relapse. A control group of 51 patients was formed at a ratio of 3:1 according to age, stage, and grade, similar to that in the study group. Of the 17 patients with recurrent disease, 13 patients (76.5%) were stage 1A, and 4 patients (23.5%) were stage 1B. No significant difference was found in age, stage, and grade between the case and control groups (p>0.05). Body mass index, parity, tumor size, lower uterine segment involvement, SqD, and Ki-67 index with p<0.25 in the univariate logistic regression analysis were included in the multivariate analysis. Ki-67 was statistically significant in multivariate analysis (p=0.018); however, there was no statistical significance in SqD and other parameters. Our data suggest that the Ki-67 index rather than SqD needs to be assessed for recurrence in patients with low- and intermediate-risk EEC.

中文翻译：

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Ki-67指数、鳞状细胞分化和一些临床病理参数对低风险和中风险子宫内膜癌复发的影响。


子宫内膜样癌 (EEC) 约占子宫内膜癌病例的 75-80%。我们的研究纳入了 2010 年至 2018 年间在作者所在机构进行随访的 336 名 EEC 患者。使用欧洲肿瘤内科学会标准鉴定了 272 名低度和中度 EEC 患者，并通过组织病理学检查进行了确认。其中 17 名患者报告复发。研究组由复发的患者组成。根据年龄、分期、级别按3：1的比例组成对照组，共51例，与研究组相似。在17名复发患者中，13名患者（76.5%）为1A期，4名患者（23.5%）为1B期。病例组与对照组的年龄、分期、分级均无显着性差异（p>0.05）。多变量分析中包括体重指数、产次、肿瘤大小、子宫下段受累、SqD 和单变量 Logistic 回归分析中 p<0.25 的 Ki-67 指数。 Ki-67 在多变量分析中具有统计学显着性（p=0.018）；然而，SqD 和其他参数没有统计学意义。我们的数据表明，对于低风险和中风险 EEC 患者的复发，需要评估 Ki-67 指数而不是 SqD。