Epilepsy is one of the most prevalent neurological disorders and can result in neuronal injury and degeneration. Consequently, research into new antiepileptic drugs capable of providing protection against neuronal injury and degeneration is extremely important. Neuronal Cx36 gap junction channels have been found to play an important role in epilepsy; thus, pharmacological interference using Cx36 gap junction channel blockers may be a promising strategy for disrupting the synchronization of neurons during seizure activity and protecting neurons. Based on these promising findings, several in vivo and in vitro studies are ongoing and the first encouraging results have been published. The results bring hope that neurons can be protected from injury and degeneration in patients with epilepsy, which is currently impossible.

中文翻译：

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神经元Cx36间隙连接通道阻滞的潜在抗癫痫作用

癫痫病是最普遍的神经系统疾病之一，可导致神经元损伤和变性。因此，对能够提供针对神经元损伤和变性的保护作用的新的抗癫痫药的研究非常重要。已经发现神经元Cx36间隙连接通道在癫痫中起重要作用。因此，使用Cx36间隙连接通道阻滞剂进行药理干预可能是一种在癫痫发作过程中破坏神经元同步并保护神经元的有前途的策略。基于这些令人鼓舞的发现，正在进行一些体内和体外研究，并且已经发表了第一个令人鼓舞的结果。该结果带来希望，可以保护神经元免受癫痫患者的伤害和变性，这是目前尚不可能的。