We report herein a simple and efficient one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones via reaction of 1,3-dimethyl-5,6-diaminouracil 1 with activated double bond systems 2 assisted by controlled microwave irradiation. The obtained heterocycles are privileged biologically relevant scaffolds. Graphical abstract A green, simple one-pot microwave-assisted synthesis of xanthines and pyrimidopetridines was developed with a high EcoScale and yields.

中文翻译：

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微波辅助反应：在受控的微波加热下，高效且通用的一步合成8取代的黄嘌呤和取代的嘧啶二甲-2,4,6,8-四酮

我们在这里报告了一个简单而有效的一步合成8-取代的黄嘌呤和取代的嘧啶蝶啶-2,4,6,8-丁酮通过1,3-二甲基-5,6-二氨基尿嘧啶1与活化的双键系统2的反应借助受控的微波辐射。所获得的杂环是生物学上相关的有优势的支架。图形摘要开发了一种绿色，简单的单锅微波辅助合成黄嘌呤和嘧啶并吡啶的方法，具有很高的EcoScale和产量。