In this study, the electrochemical behavior of sulpiride (SUL) was examined deeply by using pyrolytic graphite electrode modified with graphene oxide (GO) and β-cyclodextrin (β-CD). The developed nanosensor indicated considerable impact by significantly increasing the signal of SUL compared with the bare electrode. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV) methods were utilized to investigate the SUL electrochemical analysis in aqueous solutions. Under optimum experimental conditions, calibration plot for SUL with a limit of detection of 2.83 × 10 −9 M was obtained at accumulation time of the 30 s using square wave adsorptive stripping voltammetric technique (AdSSWV) in the range of 1.0 × 10 −7 to 5.0 × 10 −5 M. The effects of accumulation potential, accumulation time, pH, scan rate, electrolyte, and interfering agents were studied to obtain the intensive peak signal of the analyte. The presented method is validated and successfully performed for the determination of the SUL tablet and capsule. The fabricated nanosensor was carried out for the detection of SUL in the urine. Excellent recoveries among 104.37, 103.82, and 101.95% were obtained for tablet and capsule forms and urine analysis.

中文翻译：

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通过β-环糊精复合物增强氧化石墨烯对抗抑郁药舒必利的敏感性分析

在这项研究中，通过使用氧化石墨烯（GO）和β-环糊精（β-CD）修饰的热解石墨电极，对舒必利（SUL）的电化学行为进行了深入研究。与裸电极相比，已开发的纳米传感器通过显着增加SUL信号显示出可观的影响。循环伏安法（CV），差分脉冲伏安法（DPV）和方波伏安法（SWV）方法用于研究水溶液中的SUL电化学分析。在最佳实验条件下，使用方波吸附溶出伏安法（AdSSWV）在30 s的累积时间内，SUL的检出限为2.83×10 -9 M的校准图在1.0×10 -7至5.0×10 -5M。累积电势，累积时间，pH，扫描速率，对电解质和干扰剂进行了研究，以获得分析物的强烈峰信号。所提出的方法经过验证并成功地用于测定SUL片剂和胶囊剂。所制造的纳米传感器用于检测尿液中的SUL。通过片剂和胶囊剂形式以及尿液分析，获得了104.37、103.82和101.95％的极佳回收率。