This review synthesizes the available evidence about the predisposition of individuals with asthma or allergies to orthodontically induced inflammatory root resorption (OIIRR) and possible factors related to root resorption that were investigated in the included studies, such as the type of malocclusion, duration of orthodontic treatment, and tooth units. Six electronic databases and partial gray literature were searched without date or language restrictions until September 2020. Prospective and retrospective observational cohort and case-control studies were included. The risk of bias (RoB) was assessed using the checklists from the Joanna Briggs Institute and the certainty of the evidence using the GRADE tool. To complement the case-control studies, the odds ratio (OR) of the individuals with allergies/asthma to develop root resorption was calculated. Six studies were included. One study with low RoB, one with moderate, and one with high RoB stated that allergic patients did not report a greater chance of developing OIIRR (OR = 1.17 to 2.10, p = 0.1 to 1), while only one study with low RoB reported that individuals with allergies tend to develop root resorption (OR = 2.4, 95% CI = 1.08-5.37). Three studies with low RoB and one with moderate showed no significant association between asthma and OIIRR (OR = 1.05 to 3.42, p = 0.12 to 0.94). No association was identified between the type of malocclusion and the degree of OIIRR. Uniradicular dental units and a prolonged treatment time seem to be associated with an increased risk of resorption. The certainty of the evidence was considered low for both exposure factors. Evidence with a low level of certainty indicates that individuals with allergies or asthma are not more predisposed to OIIRR. Uniradicular teeth and long-term orthodontic treatments are associated with a higher risk of OIIRR. PROSPERO CRD42020188463

中文翻译：

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过敏/哮喘和牙根吸收：系统评价

本综述综合了有关哮喘或过敏个体对正畸诱导的炎性牙根吸收 (OIIRR) 的易感性的现有证据，以及纳入研究中调查的与牙根吸收相关的可能因素，例如咬合不正的类型、正畸治疗的持续时间, 和齿单位。在 2020 年 9 月之前，无日期或语言限制地搜索了六个电子数据库和部分灰色文献。包括前瞻性和回顾性观察性队列研究和病例对照研究。使用 Joanna Briggs 研究所的清单和使用 GRADE 工具的证据确定性评估偏倚风险 (RoB)。为了补充病例对照研究，计算过敏/哮喘个体发生根吸收的优势比（OR）。包括六项研究。一项低 RoB、一项中度和一项高 RoB 的研究表明，过敏患者没有报告发生 OIIRR 的机会更大（OR = 1.17 到 2.10，p = 0.1 到 1），而只有一项低 RoB 的研究报告了有过敏症的人往往会发生根吸收（OR = 2.4, 95% CI = 1.08-5.37）。三项低 RoB 研究和一项中度研究显示哮喘与 OIIRR 之间没有显着关联（OR = 1.05 至 3.42，p = 0.12 至 0.94）。未发现咬合不正类型与 OIIRR 程度之间存在关联。单根牙科治疗台和延长治疗时间似乎与再吸收风险增加有关。两种暴露因素的证据质量都被认为很低。低确定性的证据表明，患有过敏症或哮喘的人并不更容易发生 OIIRR。单根牙和长期正畸治疗与较高的 OIIRR 风险相关。PROSPERO CRD42020188463