Hydrogel has been used for in suit gastric ulcer therapy by stopping bleeding, separating from ulcer from gastric fluids and providing extracellular matrix scaffold for tissue regeneration, however, this treatment guided with endoscopic catheter in most cases. Here, we developed an oral keratin hydrogel to accelerate the ulcer healing without endoscopic guidance, which can specially adhere to the ulcer because of the high-viscosity gel formation on the wound surface in vivo. Approximately 50% of the ulcer-adhesive keratin hydrogel can resident in ethanol-treated rat stomach within 12 h, while approximately 18% of them maintained in health rat stomach in the same amount of time. Furthermore, Keratin hydrogels accelerated the ethanol-induced gastric ulcer healing by stopping the bleeding, preventing the epithelium cells from gastric acid damage, suppressing inflammation and promoting re-epithelization. The oral administration of keratin hydrogel in gastric ulcer treatment can enhance the patient compliance and reduce the gastroscopy complications. Our research findings reveal a promising biomaterial-based approach for treating gastrointestinal ulcers.

中文翻译：

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用于大鼠胃溃疡愈合的溃疡粘附口腔角蛋白水凝胶的制备

水凝胶通过止血、将溃疡与胃液分离以及为组织再生提供细胞外基质支架等作用，已用于适合胃溃疡的治疗，但在大多数情况下，这种治疗以内窥镜导管为指导。在这里，我们开发了一种口服角蛋白水凝胶，无需内镜引导即可加速溃疡愈合，由于在体内创面形成高粘度凝胶，因此可以特别粘附溃疡。大约 50% 的溃疡粘附角蛋白水凝胶可以在 12 小时内驻留在乙醇处理的大鼠胃中，而其中大约 18% 的它们在相同的时间内保持在健康的大鼠胃中。此外，角蛋白水凝胶通过止血加速乙醇诱导的胃溃疡愈合，防止上皮细胞受到胃酸损伤，抑制炎症和促进上皮再形成。在胃溃疡治疗中口服角蛋白水凝胶可以提高患者的依从性，减少胃镜检查的并发症。我们的研究结果揭示了一种有前途的基于生物材料的治疗胃肠道溃疡的方法。