An efficient catalytic asymmetric chlorocyclization of olefinic amides with 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) using hydroquinidine 1,4-phthalazinediyl diether ((DHQD)2PHAL) as organocatalyst has been developed. Series of chiral chloro substituted isobenzofuran-1(3H)-imine derivatives were obtained in good yields (up to 85%) and enantioselectivities (up to 70% ee).

中文翻译：

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（DHQD）2PHAL催化1,3-二氯-5,5-二甲基乙内酰脲（DCDMH）对酰胺的对映选择性氯环化

已经开发了一种有效的催化酰胺不对称氯环化反应，使用1,3-二氯-5,5-二甲基乙内酰脲（DCDMH）作为对苯二酚1,4-酞嗪二基二醚（（DHQD）2PHAL）作为有机催化剂。获得了一系列手性氯取代的异苯并呋喃-1（3H）-亚胺衍生物，收率高（高达85％）和对映选择性（高达70％ee）。