Abstract

Drying is an indispensable operation in the preparation of pharmaceutical powders and always remained one of the energetic tasks in the pharmaceutical industry. Improving the stability, solubility, and dissolution of pharmaceutical products are being prime objectives of the drying process, intending to produce the products loving the dry state. Although there are voluminous literatures available concerning drying operations, there is scant information available regarding the applicability of drying in drug delivery and process scale-up. The current communication embodies the different particle engineering technologies of drying viz. spray-, freeze-, and spray-freeze drying. In addition, potential uses of drying in the taste masking, and the development of inhalable powders presented briefly. Recent advancements in the drying of novel drug delivery systems is the major focus of the present review. In our opinion, the commercial aspects, regulatory guidelines, and scale-up strategies presented herein provide an opportunity to readers, researchers, and industrialists to ruin the critical issues during drying operations and aid in developing quality pharmaceutical technologies.

摘要

干燥是药粉制备中必不可少的操作，一直是制药行业的一项充满活力的任务。提高药品的稳定性、溶解性和溶出度是干燥过程的主要目标，旨在生产喜欢干燥状态的产品。尽管有大量关于干燥操作的文献可用，但关于干燥在药物输送和工艺放大中的适用性的可用信息很少。目前的交流体现了干燥即不同的粒子工程技术。喷雾、冷冻和喷雾冷冻干燥。此外，还简要介绍了干燥在掩味中的潜在用途以及可吸入粉末的开发。新型药物输送系统干燥的最新进展是本综述的主要焦点。在我们看来，本文提出的商业方面、监管指南和放大策略为读者、研究人员和工业家提供了一个机会，可以解决干燥操作过程中的关键问题，并有助于开发高质量的制药技术。