The immense potency of fentanyl and its persistent use poses great danger to abusers and law enforcement personnel. With just a few milligrams capable of causing an overdose, most agencies advise personnel to avoid handling fentanyl or related materials directly. However, there are limited field-portable and non-contact methods for the detection of fentanyl. Thus, the development of a non-contact field portable detection method is essential. To facilitate the development of a non-contact detection method, the volatile signature of fentanyl was explored using a solid phase microextraction (SPME) coupled with gas chromatography and mass spectrometry (GC–MS) method. SPME-GC–MS was used to collect and establish the vapor signature of pure pharmaceutical-grade fentanyl and diluted pharmaceutical-grade fentanyl. The collection and analysis of these vapor signatures has provided an essential stepping-stone in the future development of a non-contact vapor detection method for fentanyl.

芬太尼的巨大功效及其持续使用对滥用者和执法人员构成极大的危险。大多数机构仅需几毫克就能引起用药过量，因此建议人员避免直接处理芬太尼或相关物质。然而，用于芬太尼检测的现场便携式和非接触式方法有限。因此，非接触式现场便携式检测方法的开发是必不可少的。为促进非接触检测方法的发展，使用固相微萃取（SPME）结合气相色谱和质谱（GC-MS）方法探索了芬太尼的挥发性特征。SPME-GC-MS用于收集和建立纯药物级芬太尼和稀释的药物级芬太尼的蒸气特征。