Abstract

Euphopepluanones F − K (1 − 4), four new jatrophane type diterpenoids were isolated from the seeds of Euphorbia peplus, along with eight known diterpenoids (5 − 12). Their structures were established on the basis of extensive spectroscopic analysis and X-ray crystallographic experiments. The new compounds 1 − 4 were assessed for their activities to induce lysosomal biogenesis through LysoTracker Red staining. Compound 2 significantly induced lysosomal biogenesis. In addition, compound 2 could increase the number of LC3 dots, indicating that it could activate the lysosomal-autophagy pathway.

Graphic Abstract

中文翻译：

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大戟花种子中的Jatrophane二萜类化合物在溶酶体自噬途径中具有潜在的生物活性。

摘要

Euphopepluanones的F - K（1  -  4），四个新jatrophane型二萜类化合物是从种子分离南欧大戟，具有8个已知二萜类化合物（沿5  -  12）。它们的结构是在广泛的光谱分析和X射线晶体学实验的基础上建立的。所述新的化合物1  -  4进行了评估其活动，以通过溶酶体示踪剂红染色诱导溶酶体生物发生。化合物2显着诱导溶酶体生物发生。此外，化合物2可以增加LC3点的数量，表明它可以激活溶酶体自噬途径。

图形摘要