Spinal cord injury (SCI) can permanently impair motor and sensory function and has a devastating cost to patients and the United States healthcare system. Stem cell transplantation for treatment of SCI is a new technique aimed at creating biological functional recovery. Operative techniques in stem cell transplantation for SCI are varied. We review various clinical treatment paradigms, surgical techniques and technical considerations important in SCI treatment. The NCBI PubMed database was queried for "SCI" and "stem cell" with a filter placed for "clinical trials". Thirty-nine articles resulted from the search and 29 were included and evaluated by study authors. A total of 10 articles were excluded (9 not SCI focused or transplantation focused, 1 canine model). Key considerations for stem cell transplantation include method of delivery (intravenous, intrathecal, intramedullary, or excision and engraftment), time course of treatment, number of treatments and time from injury until treatment. There are no phase III clinical trials yet, but decreased time from injury to treatment and a greater number of stem cell injections both seem to increase the chance of functional recovery.

中文翻译：

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回顾脊髓干细胞治疗中的手术考虑因素。

脊髓损伤（SCI）可能会永久性损害运动和感觉功能，并给患者和美国医疗系统带来巨大的损失。干细胞移植治疗SCI是一项旨在实现生物学功能恢复的新技术。用于SCI的干细胞移植的手术技术多种多样。我们回顾了在SCI治疗中重要的各种临床治疗范例，手术技术和技术考虑因素。向NCBI PubMed数据库查询“ SCI”和“干细胞”，并放置用于“临床试验”的过滤器。通过搜索获得了39篇文章，其中29篇被纳入并由研究作者进行了评估。总共排除了10篇文章（9篇不关注SCI或不关注移植，1篇犬科动物模型）。干细胞移植的关键考虑因素包括递送方法（静脉内，鞘内，髓内或切除和植入），治疗时间，治疗次数以及从受伤到治疗的时间。尚无III期临床试验，但从损伤到治疗的时间减少，以及干细胞注射的增多似乎都增加了功能恢复的机会。