This study aimed to investigate the effects of balneological outpatient treatment (hydrotherapy and peloidotherapy) on clinical status and serum cytokine levels in patients with chronic low back pain (CLBP). Seventy-four patients with CLBP who accepted to participate to the study were randomly divided into two groups. The study group was given ten sessions (in 2 weeks) of hydrotherapy, peloidotherapy, and home exercise, while the control group was given only home exercise. All patients were assessed before and at the end of therapy, at the 1st and 3rd months. The primary outcomes were pain intensity on the visual analog scale (VAS) (VAS-pain, VAS-rest, VAS-exercise) and Oswestry Disability Index (ODI). The secondary outcome measures included patient’s and physician’s global assessment (VAS-PGA), (VAS-DGA), finger-to-floor distance (FFD), modified Schober test, Short Form-36 (SF-36), and the use of analgesic drug. Venous blood samples were drawn from all patients before/1st day and after therapy/12th day to measure serum interleukin (IL)-6 and IL-10 levels. Significant improvement was observed in the study group in VAS-pain, VAS-rest, VAS-exercise, VAS-PGA, VAS-DGA, ODI, and SF-36 parameters after treatment and improvement maintained for 3 months. In the control group, significant improvement was observed in VAS-pain, VAS-exercise, VAS-PGA, VAS-DGA, and ODI scores on the 12th day and continued for 3 months. Decrease in pain, pain during rest and exercise, modified Schober test, VAS-PGA, VAS-DGA, ODI scores, and the increase in SF-36 pain and general health scores showed superiority in favor of the study group in all evaluations. There was a significant increase in IL-10 values from baseline at the end of treatment in the study group. The use of non-steroidal anti-inflammatory drug (NSAID) was significantly lower in the study group compared with the use of NSAID in the control group in the 3rd month. Balneological outpatient treatment improved clinical status in CLBP patients. Although no significant correlation was clearly determined between IL-10 levels and pain score, this effect might be related to the observed increase in the anti-inflammatory cytokine IL-10 levels that was observed only in the study group.

本研究旨在探讨浴疗门诊治疗（水疗和整骨疗法）对慢性腰痛 (CLBP) 患者临床状况和血清细胞因子水平的影响。74 名接受参与研究的 CLBP 患者被随机分为两组。研究组接受了 10 次（2 周）的水疗、整骨疗法和家庭锻炼，而对照组仅接受了家庭锻炼。在治疗前和治疗结束时、第 1 个月和第 3 个月对所有患者进行评估。主要结果是视觉模拟量表 (VAS)（VAS 疼痛、VAS 休息、VAS 运动）和 Oswestry 残疾指数 (ODI) 上的疼痛强度。次要结果测量包括患者和医生的整体评估 (VAS-PGA)、(VAS-DGA)、手指到地板距离 (FFD)、改良 Schober 试验、Short Form-36 (SF-36) 和镇痛药的使用。在治疗前/第 1 天和治疗后/第 12 天从所有患者中抽取静脉血样本以测量血清白介素 (IL)-6 和 IL-10 水平。在研究组中观察到治疗后 VAS-疼痛、VAS-休息、VAS-运动、VAS-PGA、VAS-DGA、ODI 和 SF-36 参数有显着改善，并且改善维持了 3 个月。对照组在第12天观察到VAS-疼痛、VAS-运动、VAS-PGA、VAS-DGA和ODI评分有显着改善，并持续3个月。疼痛的减轻、休息和运动时的疼痛、改良的 Schober 试验、VAS-PGA、VAS-DGA、ODI 评分以及 SF-36 疼痛和一般健康评分的增加在所有评估中均显示出有利于研究组的优势。在研究组的治疗结束时，IL-10 值比基线显着增加。在第 3 个月，研究组非甾体抗炎药 (NSAID) 的使用显着低于对照组中 NSAID 的使用。浴疗门诊治疗改善了 CLBP 患者的临床状态。虽然在 IL-10 水平和疼痛评分之间没有明确确定显着相关性，但这种影响可能与观察到的抗炎细胞因子 IL-10 水平的增加有关，而这种增加仅在研究组中观察到。浴疗门诊治疗改善了 CLBP 患者的临床状态。虽然在 IL-10 水平和疼痛评分之间没有明确确定显着相关性，但这种影响可能与观察到的抗炎细胞因子 IL-10 水平的增加有关，而这种增加仅在研究组中观察到。浴疗门诊治疗改善了 CLBP 患者的临床状态。虽然在 IL-10 水平和疼痛评分之间没有明确确定显着相关性，但这种影响可能与观察到的抗炎细胞因子 IL-10 水平的增加有关，而这种增加仅在研究组中观察到。