Herpes simplex virus 1 (HSV-1) affects a large part of the adult population. Anti-HSV-1 drugs, such as acyclovir, target thymidine kinase and viral DNA polymerase. However, the emerging of resistance of HSV-1 alerts for the urgency in developing new antivirals with other therapeutic targets. Thus, this study evaluated a series of 1,4-disubstituted-1,2,3-triazole derivatives against HSV-1 acute infection and provided deeper insights into the possible mechanisms of action.

中文翻译：

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1,4-二取代-1,2,3-三唑在体外对HSV-1的抗病毒活性。

单纯疱疹病毒 1 (HSV-1) 影响大部分成年人。抗 HSV-1 药物，如阿昔洛韦，靶向胸苷激酶和病毒 DNA 聚合酶。然而，HSV-1 耐药性的出现提醒我们迫切需要开发具有其他治疗靶点的新抗病毒药物。因此，本研究评估了一系列针对 HSV-1 急性感染的 1,4-二取代-1,2,3-三唑衍生物，并对可能的作用机制提供了更深入的了解。