Benzophenone-3 (BP-3) is an important ultraviolet (UV)-screening agent using in cosmetics, however, the associated environmental pollution and the toxicity to organisms, particularly aquatic organisms, cannot be neglected. In this study, the potential risks posed to zebrafish when exposed to environmental residual concentrations of BP-3 were evaluated. Zebrafish embryos (F0) were exposed to 0, 0.056, 2.3, and 38 μg/L BP-3 until 42 days’ post-fertilization (dpf). The effects of BP-3 on the sex ratio and gene expression of F0 zebrafish were investigated. In the F1 embryos, cumulative hatching rate, body length, and heartbeats were observed. The result showed that F0 and F1 exposure to concentrations of 0.056 and 38 μg/L BP-3 elicited stronger toxicity at 96 hpf than single generation exposures. Overall, our results provide a new understanding on the effects of low BP-3 concentration chronic exposure on sex ratio and offspring developmental toxicity of the F0 zebrafish.

苯甲酮3（BP-3）是化妆品中使用的重要的紫外线（UV）屏蔽剂，但是，其相关的环境污染和对生物（特别是水生生物）的毒性不可忽视。在这项研究中，评估了斑马鱼暴露于环境残留浓度的BP-3时可能造成的潜在风险。将斑马鱼胚胎（F0）暴露于0、0.056、2.3和38μg/ L BP-3，直到受精后42天（dpf）。研究了BP-3对F0斑马鱼性别比和基因表达的影响。在F1胚胎中，观察到累计孵化率，体长和心跳。结果表明，与单代暴露相比，F0和F1暴露于0.056和38μg/ L BP-3的浓度在96 hpf下引起更强的毒性。全面的，