Background

Amyotrophic lateral sclerosis (ALS) people have a high risk of severe mental disorders, like depression, which impacts their function, quality of life, and mobility. However, there are no estimates of depression based paper published. This study aimed conduct a systematic review and meta-analysis of the prevalence of depression in ALS patients around the world.

Methods

PubMed/Medline, Web of science, Scopus, Embase, and Ovid are searched to identify papers that reporting the prevalence of depression. Studies are included in random-effects meta-analyses of the prevalence of depression. Subgroup analyses are performed on the severity of depression, instruments of depression, type of studies, and study regions.

Results

46 eligible studies reported prevalence of depression. The pooled prevalence of depression among ALS people was 34% (27%–41%). According to the severity of depression, mild, moderate, and severe depression were 29%, 16%, and 8%, respectively. For studies using BDI, PHQ, and HADS, the pooled prevalence of depression was 50%, 20%, and 15%, respectively.

Conclusions

ALS people have a high prevalence of depression. The high prevalence of depression causes a reduction of quality of life and mobility. The study identifies a population group at high risk needing special attention in clinical practice.

中文翻译：

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肌萎缩侧索硬化（ALS）患者抑郁症的患病率：系统评价和荟萃分析

背景

肌萎缩侧索硬化 (ALS) 患者患严重精神障碍（如抑郁症）的风险很高，这会影响他们的功能、生活质量和行动能力。然而，没有发表基于抑郁症的论文的估计。本研究旨在对全球 ALS 患者的抑郁症患病率进行系统回顾和荟萃分析。

方法

搜索 PubMed/Medline、Web of science、Scopus、Embase 和 Ovid，以确定报告抑郁症患病率的论文。研究包含在抑郁症患病率的随机效应荟萃分析中。对抑郁症的严重程度、抑郁症的工具、研究类型和研究区域进行亚组分析。

结果

46 项符合条件的研究报告了抑郁症的患病率。ALS 人群中抑郁症的合并患病率为 34% (27%–41%)。根据抑郁症的严重程度，轻度、中度和重度抑郁症分别占29%、16%和8%。对于使用 BDI、PHQ 和 HADS 的研究，合并的抑郁症患病率分别为 50%、20% 和 15%。

结论

ALS 患者的抑郁症患病率很高。抑郁症的高患病率导致生活质量和行动能力的下降。该研究确定了在临床实践中需要特别关注的高危人群。