Abstract

Context

Elevated serum concentrations of chemerin is a significant factor in the development of metabolic disorders in individuals with overweight and obesity.

Objective

This systematic review, meta-analysis, and meta-regression evaluated the effects of exercise training on serum concentrations of chemerin in individuals with overweight and/or obesity.

Methods

Studies published up to January 2021 were identified through four databases. Forty-three studies including 1271 participants were included and analysed using a random-effects model to calculate weighted mean differences with 95% confidence intervals.

Results

Results indicated that exercise training significantly decreased serum concentrations of chemerin in individuals with overweight and/or obesity. Subgroup analysis showed that all types of exercise (aerobic, resistance, and combined training) interventions but not high-intensity interval training decreased serum concentrations of chemerin. Subgroup analysis based on baseline body mass index (BMI), gender, and intervention duration showed significant declines in serum concentrations of chemerin. Meta-regression analysis indicated a linear relationship between changes in body fat percentage (BFP) with serum concentrations of chemerin.

Conclusion

Exercise training may decrease serum concentrations of chemerin in individuals with overweight and/or obesity. The chemerin-lowering effects of exercise might be related to declines in BFP. Further studies are needed to confirm these findings.

中文翻译：

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运动训练对超重和肥胖个体凯莫瑞血清浓度的影响：43 项临床试验的系统评价、荟萃分析和荟萃回归

摘要

语境

凯莫瑞血清浓度升高是超重和肥胖个体发生代谢紊乱的重要因素。

客观的

这项系统评价、荟萃分析和荟萃回归评估了运动训练对超重和/或肥胖个体凯莫瑞血清浓度的影响。

方法

截至 2021 年 1 月发表的研究是通过四个数据库确定的。纳入了 43 项研究，包括 1271 名参与者，并使用随机效应模型进行分析，以计算具有 95% 置信区间的加权平均差异。

结果

结果表明，运动训练显着降低了超重和/或肥胖个体的凯莫瑞血清浓度。亚组分析表明，所有类型的运动（有氧运动、抗阻运动和综合训练）干预措施（但高强度间歇训练不会）降低凯莫瑞的血清浓度。基于基线体重指数 (BMI)、性别和干预持续时间的亚组分析显示凯莫瑞血清浓度显着下降。荟萃回归分析表明体脂百分比（BFP）的变化与凯莫瑞血清浓度之间存在线性关系。

结论

运动训练可能会降低超重和/或肥胖个体的凯莫瑞血清浓度。运动降低凯莫瑞的作用可能与 BFP 的下降有关。需要进一步的研究来证实这些发现。