Background Data on myopia prevalence and progression in European children are sparse. The aim of this work was to evaluate the progression of myopia in children and teenagers in a large prospective study. Methods A prospective study involving a nationwide cohort. Myopia was defined as a spherical equivalent (SE) of ≤ –0.50 diopters (D). Data on refractive error, gender and age were collected in 696 optical centres in France between 2013 and 2019, including 136 333 children (4–17 years old) in the analysis. Progression of myopia was assessed between the first visit and the last visit over up to 6.5 years. Results Mean age was 11.3±3.8 years (55.0% of female). The proportion of children progressing more than –0.50 D per year was higher in age groups 7–9 years and 10–12 years and in children with SE ≤ –4.00 D at first visit, representing 33.1%, 29.4% and 30.0% of these groups, respectively. In multivariate analysis, progression during the first 11–24 months was higher in the 7–9 and 10–12 age groups (–0.43 D and –0.42 D, respectively), for higher SE at baseline (at least –0.33 D for SE ≤ –1 D) and for girls (–0.35 D). Conclusion This is the first French epidemiological study to investigate myopia progression in a large-scale cohort of children. Sex, age groups and myopia severity are associated with differing rates of progression. Data may be available on request for further analyses please contact nicolas.leveziel@yahoo.fr.

中文翻译：

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儿童和青少年近视的进展：一项全国性纵向研究

背景 关于欧洲儿童近视患病率和进展的数据很少。这项工作的目的是在一项大型前瞻性研究中评估儿童和青少年近视的进展。方法 一项涉及全国性队列的前瞻性研究。近视定义为 ≤ –0.50 屈光度 (D) 的球面等效值 (SE)。2013 年至 2019 年期间，在法国 696 个光学中心收集了屈光不正、性别和年龄的数据，其中包括 136 333 名儿童（4-17 岁）参与分析。在长达 6.5 年的第一次访问和最后一次访问之间评估近视的进展。结果平均年龄为11.3±3.8岁（女性占55.0%）。在 7-9 岁和 10-12 岁年龄组以及首次就诊时 SE ≤ -4.00 D 的儿童中，每年进展超过 –0.50 D 的儿童比例较高，占 33.1%, 29。分别占这些组的 4% 和 30.0%。在多变量分析中，7-9 岁和 10-12 岁年龄组的前 11-24 个月的进展更高（分别为–0.43 D 和 –0.42 D），因为基线 SE 较高（SE 至少为 –0.33 D ≤ –1 D) 和女孩 (–0.35 D)。结论 这是第一个在大规模儿童队列中调查近视进展的法国流行病学研究。性别、年龄组和近视严重程度与不同的进展率有关。可根据要求提供数据以进行进一步分析，请联系 nicolas.leveziel@yahoo.fr。结论 这是第一个在大规模儿童队列中调查近视进展的法国流行病学研究。性别、年龄组和近视严重程度与不同的进展率有关。可根据要求提供数据以进行进一步分析，请联系 nicolas.leveziel@yahoo.fr。结论 这是第一个在大规模儿童队列中调查近视进展的法国流行病学研究。性别、年龄组和近视严重程度与不同的进展率有关。可根据要求提供数据以进行进一步分析，请联系 nicolas.leveziel@yahoo.fr。