Aim: The Val66Met single-nucleotide polymorphism (SNP) on the BDNF gene has established pleiotropic effects on schizophrenia incidence and morphologic alterations in the illness. The effects of brain-derived neurotrophic factor (BDNF) on brain volume measurements are however mixed seeming to be less established for most brain regions. The current meta-analytic review examined (1) the association of the Val66Met SNP and brain volume alterations in schizophrenia by comparing Met allele carriers to Val/Val homozygotes and (2) the association of serum BDNF with brain volume measurements. Method: Studies included in the meta-analyses were identified through an electronic search of PubMed and PsycInfo (via EBSCO) for English language publications from January 2000 through December 2017. Included studies had conducted a genotyping procedure of Val66Met or obtained assays of serum BDNF and obtained brain volume data in patients with psychotic disorders. Nonhuman studies were excluded. Results: Study 1 which included 52 comparisons of Met carriers and Val/Val homozygotes found evidence of lower right and left hippocampal volumes among Met allele carriers with schizophrenia. Frontal measurements, while also lower among Met carriers, did not achieve statistical significance. Study 2 which included 7 examinations of the correlation between serum BDNF and brain volume found significant associations between serum BDNF levels and right and left hippocampal volume with lower BDNF corresponding to lower volumes. Discussion: The meta-analyses provided evidence of associations between brain volume alterations in schizophrenia and variations on the Val66Met SNP and serum BDNF. Given the limited number of studies, it remains unclear if BDNF effects are global or regionally specific.
Neuropsychobiology

中文翻译：

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脑源性神经营养因子对精神分裂症脑容量影响的荟萃分析：基因型和血清水平

目的： BDNF基因上的 Val66Met 单核苷酸多态性 (SNP)已确定对精神分裂症发病率和疾病形态学改变的多效性。然而，脑源性神经营养因子 (BDNF) 对脑容量测量的影响参差不齐，似乎对于大多数大脑区域来说还不太确定。目前的荟萃分析审查通过比较 Met 等位基因携带者与 Val/Val 纯合子和 (2) 血清 BDNF 与脑容量测量值的关联，检查了 (1) Val66Met SNP 与精神分裂症脑容量改变的关联。方法：从 2000 年 1 月到 2017 年 12 月，通过对 PubMed 和 PsycInfo（通过 EBSCO）的英语出版物进行电子搜索，确定了荟萃分析中包含的研究。纳入的研究进行了 Val66Met 的基因分型程序或获得了血清 BDNF 的测定并获得了大脑精神病患者的大量数据。非人类研究被排除在外。结果：研究 1 包括 52 项 Met 携带者和 Val/Val 纯合子的比较，发现患有精神分裂症的 Met 等位基因携带者的右海马体积和左海马体积较低。额叶测量值虽然在 Met 携带者中也较低，但没有达到统计学意义。研究 2 包括对血清 BDNF 与脑容量之间相关性的 7 项检查，发现血清 BDNF 水平与左右海马体积之间存在显着关联，较低的 BDNF 对应于较低的体积。讨论：荟萃分析提供了精神分裂症脑容量改变与 Val66Met SNP 和血清 BDNF 变化之间关联的证据。鉴于研究数量有限，尚不清楚 BDNF 效应是全球性的还是区域性的。
神经心理生物学