Atropisomeric styrenes are a class of optically active compounds, the chirality of which results from restricted rotation of the C(vinyl)–C(aryl) single bond. In comparison with biaryl atropisomers, the less rigid skeleton of styrenes usually leads them to have lower rotational barriers. Although it has been overlooked for a long time, scientists have paid attention to this class of unique molecules in recent years and have developed many methods for the preparation of optically active atropisomeric styrenes. In this article, we review the development of the concept of atropisomeric styrenes, along with their isolation, asymmetric synthesis, and synthetic applications.

1 Introduction

2 The Concept of Styrene Atropisomerism

3 Early Research: Separation of Optically Active Styrenes

4 Synthesis of Optically Active Styrenes

5 Stability of the Chirality of Atropisomeric Styrenes

6 Outlook

阻转异构苯乙烯是一类光学活性化合物，其手性来自C（乙烯基）-C（芳基）单键的受限旋转。与联芳基阻转异构体相比，苯乙烯刚性较低的骨架通常会使它们的旋转势垒降低。尽管它已被长期忽视，但近年来，科学家已注意到这类独特的分子，并开发了许多制备旋光性阻转异构苯乙烯的方法。在本文中，我们回顾了阻转异构苯乙烯概念的发展以及它们的分离，不对称合成和合成应用。

1引言

2苯乙烯阻转异构的概念

3早期研究：旋光苯乙烯的分离

4光学活性苯乙烯的合成

5阻转异构苯乙烯的手性稳定性

6展望