As the introduction of concentrated cattle pour-on products containing abamectin, there have been veterinary reports of both fatal and non-fatal poisoning in New Zealand working dogs. Because these products are highly palatable to dogs, a toxic dose is readily ingested. The pharmacokinetic properties of abamectin in dogs are not published in the public domain. This information is important in understanding the processes of absorption and elimination when treating poisoned dogs and is useful in determining an appropriate treatment for poisoned dogs. The pharmacokinetic properties of abamectin administered orally to six healthy dogs (3 male and 3 female) at a dose of 0.2 mg/kg were established. Plasma concentrations of abamectin were determined by high-performance liquid chromatography (HPLC) coupled with a fluorescence detector. The maximum plasma concentration (C_max) for abamectin was 135.52 ± 38.6 ng/ml at 3.16 ± 0.75 h. The elimination half-life (T1/2 elim (h)) was 26.51 ± 6.86 h. The area under the curve (AUC 0-∞) was 3723.50 ± 1213.08 ng h/ml. The mean residence time (MRT) was 38.82 ± 8.93 h. These pharmacokinetic data provide helpful information regarding the treatment of poisoned dogs.

中文翻译：

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阿维菌素在犬体内的药代动力学特性

随着含有阿维菌素的浓缩牛浇注产品的推出，已有兽医报告称新西兰工作犬出现致命和非致命中毒。因为这些产品对狗来说非常可口，所以很容易摄入有毒剂量。阿维菌素在犬体内的药代动力学特性未公开发表。这些信息对于了解治疗中毒犬的吸收和消除过程很重要，并且有助于确定对中毒犬的适当治疗。确定了以 0.2 mg/kg 的剂量给 6 只健康狗（3 只雄性和 3 只雌性）口服给药的阿维菌素的药代动力学特性。阿维菌素的血浆浓度通过高效液相色谱 (HPLC) 与荧光检测器联用进行测定。在 3.16 ± 0.75 小时时，阿维菌素的_最大值) 为 135.52 ± 38.6 ng/ml。消除半衰期 (T1/2 elim (h)) 为 26.51 ± 6.86 小时。曲线下面积 (AUC 0-∞) 为 3723.50 ± 1213.08 ng h/ml。平均停留时间 (MRT) 为 38.82 ± 8.93 小时。这些药代动力学数据提供了有关中毒犬治疗的有用信息。