Pregnancy toxaemia (PT) is a metabolic disorder affecting does during late gestation. This study describes the histopathological changes in pregnant does and their foetuses experimentally-induced with PT. Eight does in their late pregnancy were induced into PT by reducing the energy intake (Group 1), while 6 does were maintained with adequate energy intake (Group 2). The blood beta-hydroxybutyric acid (BHBA) and glucose concentrations were measured every 5 days throughout the 20-day study period. All does that experienced stillbirth were immediately euthanised, while the does and the full-term, non-aborted foetuses were euthanised on day 20. Samples of umbilical cords, placentas and uteri were collected from the does, while hearts and livers were collected from the foetuses. The samples were subjected to histopathological assessment, and subsequently correlated with the blood BHBA concentration. Stillbirth occurred in 5 (62.5 %) does of Group 1. The remaining does of Group 1 and all does of Group 2 did not experience stillbirth until the end of the experiment. Overall lesions in the umbilical cord were significantly (p < 0.01) more severe in Group 1. Does of Group 1 that experienced stillbirth showed chorionic villi necrosis and homogenous chorionic villi hypomaturity, while the endometrial glands were non-secreting. The stillborn foetuses showed extensive hepatic necrosis. The last concentrations of BHBA and glucose showed significant (p < 0.05) difference between the two groups. The histopathological lesions in the placenta, uterus, and foetal liver were significantly (p < 0.05−0.01) correlated with the blood BHBA concentration. The histopathology lesions could suggest the mechanism of stillbirth in PT and raise concern that it could affect the performance of the off-springs should stillbirth did not occur.

妊娠毒血症（PT）是一种代谢异常，会影响妊娠后期的行为。这项研究描述了孕妇的组织病理学变化以及实验性诱导的PT胎儿。怀孕后期有八只确实通过减少能量摄入而诱发了PT（第1组），而六只确实保持了足够的能量摄入（第2组）。在整个20天的研究期内，每5天测量一次血液中的β-羟基丁酸（BHBA）和葡萄糖浓度。立即对所有死胎进行安乐死，并在第20天对未死胎和足月无胎胎儿进行安乐死。老兄们。对样品进行组织病理学评估，然后与血液中的BHBA浓度相关。死胎发生在第1组的5例中（62.5％），直到实验结束，第1组的其余各例和第2组的所有胎均未发生死胎。在第1组中，脐带的总体病变更为严重（p <0.01）。在第1组中，发生死产的人的绒毛膜坏死和绒毛膜绒毛均质性过低，而子宫内膜腺体不分泌。死产的胎儿表现出广泛的肝坏死。BHBA和葡萄糖的最后浓度在两组之间显示出显着（p <0.05）差异。胎盘，子宫和胎儿肝脏的组织病理学病变与血BHBA浓度显着相关（p <0.05-0.01）。