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Human papillomavirus symptomatic infection associated with increased risk of new-onset alopecia areata: A nationwide population-based cohort study
Journal of Autoimmunity ( IF 7.9 ) Pub Date : 2021-03-11 , DOI: 10.1016/j.jaut.2021.102618
Ting-Yu Tu, Renin Chang, Jung-Nien Lai, Chu-Chiao Tseng, Ming-Li Chen, Hei-Tung Yip, Yao-Min Hung, James Cheng-Chung Wei

Background

We investigated the correlation between a history of human papillomavirus (HPV) infection and alopecia areata risk.

Methods

The study cohort comprised 30,001 patients with newly diagnosed HPV infection between 2000 and 2012; and with use of computer-generated randomly numbers, patients not had HPV infection were randomly selected as the comparison cohort. HPV infection cohort were matched to comparison individuals at a 1:1 ratio by age, gender and index year. All study individuals were followed up until they developed alopecia areata, withdraw from the insurance program, lost to follow-up, or until the end of 2013. Cox proportional hazards regression analysis was used to analyze the risk of alopecia areata with hazard ratios (HRs) and 95% confidence intervals (CIs) between the HPV and control cohort.

Results

The adjusted hazard ratio (aHR) of alopecia areata for HPV patients relative to controls was 2.55 (95% C.I. = 1.88–3.47) after adjusting sex, age and comorbidities. Subgroup analysis indicated that patients with HPV infections had a significantly greater risk of alopecia areata for both genders, all age subgroups, and those with mental disorder diseases.

Conclusions

A history of HPV infection is associated with the development of subsequent alopecia areata in Taiwanese subjects.

更新日期:2021-03-11
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