Lumefantrine is used to treat uncomplicated malaria caused by pure or mixed Plasmodium falciparum infections and as a prophylactic against recrudescence following artemether therapy. However, the pharmaceutical is released into the aquatic environment from industrial effluents, hospital discharges, and human excretion. This study assessed the effects of lumefantrine on the growth and physiological responses of the microalgae Chlorella vulgaris and Raphidocelis subcapitata (formerly known as Selenastrum capricornutum and Pseudokirchneriella subcapitata) and the aquatic macrophyte Lemna minor. The microalgae and macrophyte were exposed to 200−10000 μg l⁻¹ and 16−10000 μg l⁻¹ lumefantrine, respectively. Lumefantrine had a variable effect on the growth of the aquatic plants investigated. There was a decline in the growth of R. subcapitata and L. minor post-exposure to the drug. Contrarily, there was stimulation in the growth of Chlorella vulgaris. All experimental plants had a significant increase in lipid peroxidation, which was accompanied by an increase in malondialdehyde content. Peroxidase activity of L. minor increased only at low lumefantrine concentrations, while the opposite occurred at higher levels of the drug. Incubation in lumefantrine contaminated medium significantly up-regulated the activity of R. subcapitata cultures. Glutathione S-transferase of L. minor exposed to lumefantrine treatments had substantially higher activities than the controls. Our findings suggest lumefantrine could have adverse but variable effects on the growth and physiology of the studied aquatic plants.

Lumefantrine 用于治疗由纯或混合恶性疟原虫感染引起的无并发症疟疾，并作为预防蒿甲醚治疗后复发的药物。然而，药物会从工业废水、医院排放物和人类排泄物中释放到水生环境中。本研究评估了苯芴醇对微藻Chlorella vulgaris和Raphidocelis subcapitata（以前称为Selenastrum capricornutum和Pseudokirchneriella subcapitata）和水生大型植物Lemna minor的生长和生理反应的影响。微藻和大型植物暴露于 200-10000 μg l ^-1和 16-10000 μg l ^-1芴芴醇，分别。Lumefantrine 对所研究的水生植物的生长有不同的影响。接触该药物后，R. subcapitata和L. minor的生长出现下降。相反，对普通小球藻的生长有刺激作用。所有实验植物的脂质过氧化显着增加，伴随着丙二醛含量的增加。L. minor 的过氧化物酶活性仅在低浓度芴芴醇时增加，而在药物浓度较高时则相反。在 lumefantrine 污染培养基中培养显着上调R. subcapitata的活性文化。暴露于lumefantrine 处理的L. minor 的谷胱甘肽S-转移酶具有比对照高得多的活性。我们的研究结果表明，苯芴醇可能对所研究的水生植物的生长和生理产生不利但可变的影响。