Pneumatically agitated slurry reactors, including bubble column reactors and airlift loop reactors (ALRs), are important gas–liquid–solid multiphase reactors. These reactors have been widely applied in many processes, especially in the biological fermentation and energy chemical industry, due to their low shear stress, good mixing, perfect mass-/heat-transfer properties, and relatively low costs. To further improve the performance of slurry reactors (i.e., mixing and mass/heat transfer) and to satisfy industrial requirements (e.g., temperature control, reduction of back-mixing, and product separation), the process intensification of slurry reactors is essential. This article starts by reviewing the latest advancements in the intensification of mixing and mass/heat transfer in these two types of reactors. It then summarizes process-intensification methods for mixing and separation that allow continuous production in these slurry reactors. Process-intensification technology that integrates directional flow in an ALR with simple solid–liquid separation in a hydrocyclone is recommended for its high efficiency and low costs. This article also systematically addresses vital considerations and challenges, including flow regime discrimination, gas spargers, solid particle effects, and other concerns in slurry reactors. It introduces the progress of numerical simulation using computational fluid dynamics (CFD) for the rational design of slurry reactors and discusses difficulties in modeling. Finally, it presents conclusions and perspectives on the design of industrial slurry reactors.

包括鼓泡塔反应器和气举回路反应器（ALR）在内的气动搅拌浆反应器是重要的气液固多相反应器。这些反应器由于其低剪切应力，良好的混合，完美的传质/传热性能以及相对较低的成本而被广泛应用于许多过程中，尤其是在生物发酵和能源化学工业中。为了进一步提高淤浆反应器的性能（即混合和传质/传热）并满足工业要求（例如温度控制，减少返混和产品分离），淤浆反应器的工艺强化是必不可少的。本文首先回顾这两类反应器在混合强化和传质/传热方面的最新进展。然后概述了用于混合和分离的工艺强化方法，这些方法可以在这些淤浆反应器中连续生产。推荐使用过程增强技术，该技术将ALR中的定向流与水力旋流器中的简单固液分离相结合，以提高效率和降低成本。本文还系统地解决了重要的考虑因素和挑战，包括流态辨别，气体喷射，固体颗粒效应以及淤浆反应器中的其他问题。它介绍了使用计算流体动力学（CFD）进行浆液反应器合理设计的数值模拟的进展，并讨论了建模中的困难。最后，它提出了关于工业淤浆反应器设计的结论和观点。