Abstract

Scientists look for new materials that can be used for the synthesis of drug carriers. Growing popularity is observed for poly(hydroxybutyric acid) (PHB). This biocompatible and biodegradable biopolymer may support the proper growth and proliferation of epidermal cells. In the research, composites based on PHB and containing nanogold have been synthesized. Nanocomposites differed in the molecular weight of the crosslinking agent used for the formation of polymer network and in the amount of nanogold introduced into the polymer matrix. Swelling properties, behavior in simulated body fluids and surface morphology of nanocomposites have been analyzed. It can be concluded that by the application of suitable crosslinker and specific amount of nanogold it is possible to control the sorption capacity of analyzed samples and affect their behavior in simulated body fluids. Type of crosslinker used affected the crosslinking density and determined the compactness of the polymer structure influencing the sorption properties and degradation. Nanogold present in polymer matrix also affected its pace of degradation. It is essential in viewpoint of the application of these materials in medicine, for example, as drug carriers because it is possible to obtain several variants of such materials that will be personalized for patients depending on their needs.

摘要

科学家们正在寻找可用于合成药物载体的新材料。观察到聚（羟基丁酸）（PHB）越来越受欢迎。这种生物相容性和可生物降解的生物聚合物可以支持表皮细胞的正常生长和增殖。在研究中，已经合成了基于PHB和含有纳米金的复合材料。纳米复合材料的不同之处在于用于形成聚合物网络的交联剂的分子量和引入聚合物基质中的纳米金的量。已经分析了纳米复合材料的膨胀特性、在模拟体液中的行为和表面形态。可以得出结论，通过应用合适的交联剂和特定量的纳米金，可以控制分析样品的吸附能力并影响它们在模拟体液中的行为。所用交联剂的类型影响交联密度并确定影响吸附性能和降解的聚合物结构的紧密度。聚合物基质中存在的纳米金也影响了其降解速度。考虑到这些材料在医学中的应用，例如作为药物载体，这是必不可少的，因为可以获得这种材料的几种变体，这些变体将根据患者的需要进行个性化。所用交联剂的类型影响交联密度并确定影响吸附性能和降解的聚合物结构的紧密度。聚合物基质中存在的纳米金也影响了其降解速度。考虑到这些材料在医学中的应用，例如作为药物载体，这是必不可少的，因为可以获得这种材料的几种变体，这些变体将根据患者的需要进行个性化。所用交联剂的类型影响交联密度并确定影响吸附性能和降解的聚合物结构的紧密度。聚合物基质中存在的纳米金也影响了其降解速度。考虑到这些材料在医学中的应用，例如作为药物载体，这是必不可少的，因为可以获得这种材料的几种变体，这些变体将根据患者的需要进行个性化。