Abstract

Aim

The aim of this study was to evaluate age-related changes in lumbar paravertebral muscle (LPM) morphology in healthy younger and older adult men.

Methods

T2-weighted axial MRI of the lumbar spine were obtained for 12 healthy older (67.3 ± 6.0 years) and younger (24.7 ± 3.1 years) men. Normalised muscle volume (NMV) and muscle fat infiltrate (MFI) were determined bilaterally for the psoas (PS), quadratus lumborum (QL), erector spinae (ES) and multifidus (MF). MANOVA was used to compare NMV and MFI between age groups. Follow-up ANOVA compared NMV and MFI for each muscle between age groups, with physical activity (PA) as a covariate. Stepwise regression was used to explore the association between muscle morphology.

Results

NMV of the ES and QL were significantly lower in the older group (OG) (p = 0.040 and p < 0.001, respectively). MFI across all muscles was significantly greater in the OG (p < 0.001). PA did not moderate the relationship between aging and muscle degeneration. Non-dominant handgrip strength was associated with NMV (p = 0.003).

Conclusions

Age-related atrophy is muscle specific in the lumbar spine; changes in lumbar musculature is independent of PA, handgrip strength may reflect morphological changes in the postural muscles with age. This study supports establishing effective targeted exercise interventions in the lumbar musculature.

中文翻译：

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健康年轻男性与老年男性腰部肌肉形态的年龄相关性退化

摘要

目标

本研究的目的是评估健康的年轻和年长成年男性腰椎旁肌 (LPM) 形态与年龄相关的变化。

方法

对 12 名健康的老年（67.3 ± 6.0 岁）和年轻（24.7 ± 3.1 岁）男性进行了腰椎 T2 加权轴向 MRI。双侧测定腰肌 (PS)、腰方肌 (QL)、竖脊肌 (ES) 和多裂肌 (MF) 的标准化肌肉体积 (NMV) 和肌肉脂肪浸润 (MFI)。MANOVA 用于比较年龄组之间的 NMV 和 MFI。后续 ANOVA 比较了年龄组之间每块肌肉的 NMV 和 MFI，身体活动 (PA) 作为协变量。逐步回归用于探索肌肉形态之间的关联。

结果

老年组 (OG) 的 ES 和 QL 的 NMV 显着降低（分别为p  = 0.040 和p  < 0.001）。OG 中所有肌肉的 MFI 显着增加 ( p  < 0.001)。PA 没有缓和衰老和肌肉退化之间的关系。非优势握力与 NMV 相关（p  = 0.003）。

结论

年龄相关性萎缩是腰椎肌肉特有的；腰部肌肉组织的变化与 PA 无关，握力可能反映了姿势肌肉随年龄增长的形态变化。这项研究支持在腰部肌肉组织中建立有效的有针对性的运动干预措施。