Tetrahedral DNA nanostructure improves transport efficiency and anti‐fungal effect of histatin 5 against Candida albicans,Cell Proliferation

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Tetrahedral DNA nanostructure improves transport efficiency and anti‐fungal effect of histatin 5 against Candida albicans
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-03-11 , DOI: 10.1111/cpr.13020
Bowen Zhang ₁ , Xin Qin ₁ , Mi Zhou ₁ , Taoran Tian ₁ , Yue Sun ₁ , Songhang Li ₁ , Dexuan Xiao ₁ , Xiaoxiao Cai ₁

Affiliation

Anti‐microbial peptides (AMPs) have been comprehensively investigated as a novel alternative to traditional antibiotics against microorganisms. Meanwhile, Tetrahedral DNA nanostructures (TDNs) have gained attention in the field of biomedicine for their premium biological effects and transportation efficiency as delivery vehicles. Hence, in this study, TDN/Histatin 5 (His‐5) was synthesized and the transport efficiency and anti‐fungal effect were measured to evaluate the promotion of His‐5 modified by TDNs.

中文翻译：

四面体 DNA 纳米结构提高组蛋白 5 对白色念珠菌的运输效率和抗真菌作用

抗微生物肽（AMP）作为传统抗微生物抗生素的新型替代品已得到全面研究。与此同时，四面体DNA纳米结构（TDN）因其优异的生物效应和作为运载工具的运输效率而在生物医学领域受到关注。因此，本研究合成了TDN/Histatin 5（His-5），并测量了运输效率和抗真菌效果，以评估TDNs修饰的His-5的促进作用。

更新日期：2021-05-02

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