Ucuùba Fat Characterization and Use to Obtain Lipid Nanoparticles by High‐Pressure Homogenization with Full Factorial Design,Chemical Engineering & Technology

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Ucuùba Fat Characterization and Use to Obtain Lipid Nanoparticles by High‐Pressure Homogenization with Full Factorial Design
Chemical Engineering & Technology ( IF 1.8 ) Pub Date : 2021-03-11 , DOI: 10.1002/ceat.202000404
Rayanne R. Pereira _{1,

2} , Antonio T. A. Gomes ₃ , Matteo Testi ₂ , Annalisa Bianchera _{2,

4} , Roseane M. Ribeiro-Costa ₃ , Cristina Padula ₂ , José O. C. Silva Júnior ₁ , Fabio Sonvico _{2,

4}

Affiliation

Ucuùba fat was characterized and used as the lipid phase for the production of nanostructured lipid carriers (NLCs). The acid, iodine, refraction, and saponification values as well as the oxidative stability of the fat were determined. The myristic acid was found to be the main fatty acid present in the fat. NLCs were produced by high‐pressure homogenization with tocopheryl polyethylene glycol 1000 succinate (TPGS) or Tween 80 as surfactant. A full factorial experimental design 2² was applied to evaluate the impact of production parameters on particle size and polydispersity index (PDI) of the nanocarrier. The design of experiments (DoE) demonstrated that the increase of pressure and number cycle homogenization positively contributed to reduce the mean particle size and PDI of NLCs only when TPGS was present.

中文翻译：

Ucuùba脂肪表征及通过高压均质与全因子设计获得脂质纳米颗粒的用途

乌库巴（Ucuùba）脂肪已被表征并用作脂质相，用于生产纳米结构脂质载体（NLC）。测定了酸，碘，折光率和皂化值以及脂肪的氧化稳定性。发现肉豆蔻酸是存在于脂肪中的主要脂肪酸。NLC是通过生育酚聚乙二醇1000琥珀酸酯（TPGS）或吐温80作为表面活性剂通过高压均质化生产的。应用全因子实验设计2 ²来评估生产参数对纳米载体的粒径和多分散指数（PDI）的影响。实验设计（DoE）表明，仅当存在TPGS时，压力的增加和数字循环的均质化才能积极地降低NLC的平均粒径和PDI。

更新日期：2021-05-17

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