The cytotoxic effect of the potential antitumor drug aurumacryl (gold polyacrylate) on human skin fibroblast cell line hFB-hTERT6 has been studied in vitro. It has been found that aurumacryl exhibits substantial cytotoxicity to human skin fibroblasts. The maximum cytotoxic effect (75% cell death) is observed at an aurumacryl concentration of 0.125 mg/mL. The inhibitory concentration of aurumacryl that causes 50% human skin fibroblast death (IC₅₀) is 0.09 mg/mL.

中文翻译：

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聚丙烯酸金（Aurumacryl）对人皮肤成纤维细胞的细胞毒性作用

在体外研究了潜在的抗肿瘤药物金黄色丙烯酸（聚丙烯酸酯金）对人皮肤成纤维细胞细胞hFB-hTERT6的细胞毒性作用。已经发现，aurumacryl对人皮肤成纤维细胞显示出实质性的细胞毒性。在0.125 mg / mL的金丙烯酸浓度下观察到最大的细胞毒性作用（75％的细胞死亡）。导致50％的人类皮肤成纤维细胞死亡（IC ₅₀）的金丙烯酸抑制浓度为0.09 mg / mL。