In this study, pangas and feed samples were analyzed to estimate the levels of metallic elements and to profile the human health risks due to consumption of contaminated fish. This investigation confirmed significant variations in heavy metal concentrations among different tissues of pangas in the order of Ni > Cu > Pb > Cd > Cr in pre-monsoon and Ni > Cd = Cu > Pb = Cr in post-monsoon. Considerably higher concentrations of Pb, Cu, and Cr were estimated in liver; and Cd and Ni were detected in muscle than in other organs (p > 0.05). Statistically significant higher amounts of Cd, Ni, and Cu were observed in pre-monsoon than in post-monsoon. Furthermore, three metal pairs showed significant association (Pb–Ni and Pb–Cu involved positively; Cd–Ni acted negatively). In pre-monsoon, Cd, Pb, Ni, and Cu concentrations of feed significantly differed than those of pangas contents, whereas only Cu varied during the post-monsoon. Regression analysis revealed the significant effect of Ni content in feed on the Cu deposition of pangas (p-value 0.027, that was < 0.05). For the assessment of potential human health risk of the studied metals, estimated daily intake (EDI), target hazard quotient (THQ), hazard index (HI), and carcinogenic risk (CR) indices were calculated. Studied EDI indicated that an average adult ingested a higher amount of Ni and Cu than the recommended intake limit. Nevertheless, only the higher EDI of Ni increases the value of THQ and HI than standard limit indicates adverse non-carcinogenic risk. However, lower CR of Pb confirmed no serious health hazard due to the ingestion of pangas. Factor analysis through principal component and cluster analysis suggested that higher concentrations of Pb and Ni may be regulated by the feed used, geochemical properties, or rapid industrialization in the study area. A proper monitoring for controlling the quality of fish feed with sustainable planning for industrialization could secure the booming of pangasius aquaculture in Bangladesh.

在这项研究中，分析了沼气和饲料样本，以估计金属元素的含量，并分析由于食用受污染的鱼类而对人类健康造成的危害。这项研究证实了季风前不同组织的重气中重金属浓度的显着差异，依次为Ni> Cu> Pb> Cd> Cr，季风后Ni> Cd = Cu> Pb = Cr。估计肝脏中铅，铜和铬的浓度较高。肌肉中检出的镉和镍高于其他器官（p > 0.05）。在季风之前，季风后观测到的Cd，Ni和Cu含量在统计上显着高于季风后。此外，三对金属显示出显着的缔合（Pb-Ni和Pb-Cu呈正相关； Cd-Ni呈负相关）。在季风前，饲料中Cd，Pb，Ni和Cu的浓度与甲烷含量显着不同，而季风后只有Cu发生变化。回归分析表明，饲料中镍含量对沼气中铜的沉积有重要影响（p值0.027，即<0.05）。为了评估研究金属的潜在人类健康风险，计算了估计的每日摄入量（EDI），目标危险商（THQ），危险指数（HI）和致癌风险（CR）指数。研究的EDI表明，平均成年人摄入的镍和铜量超过建议的摄入量上限。但是，只有Ni的EDI较高才能使THQ和HI的值超过标准限值，这表明不良的非致癌风险。然而，较低的Pb CR证实没有因摄入Pangas造成严重的健康危害。通过主成分和聚类分析进行的因素分析表明，研究区域内所用的饲料，地球化学性质或快速的工业化可能会影响较高的Pb和Ni浓度。